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The human thalamus is an integrative hub for functional brain networks

Kai Hwang, Maxwell A. Bertolero, William Liu, Mark D'Esposito
doi: https://doi.org/10.1101/056630
Kai Hwang
University of California Berkeley
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  • For correspondence: kai.hwang@gmail.com
Maxwell A. Bertolero
University of California Berkeley
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William Liu
University of California Berkeley
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Mark D'Esposito
University of California Berkeley
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Abstract

The thalamus is globally connected with distributed cortical regions, yet the functional significance of this extensive thalamocortical connectivity remains largely unknown. By performing graph-theoretic analyses on thalamocortical functional connectivity data collected from human participants, we found that the human thalamus displays network properties capable of integrating multimodal information across diverse cortical functional networks. From a meta-analysis of a large dataset of functional brain imaging experiments, we further found that the thalamus is involved in multiple cognitive functions. Finally, we found that focal thalamic lesions in humans have widespread distal effects, disrupting the modular organization of cortical functional networks. This converging evidence suggests that the human thalamus is a critical hub region that could integrate heteromodal information and maintain the modular structure of cortical functional networks.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted September 22, 2016.
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The human thalamus is an integrative hub for functional brain networks
Kai Hwang, Maxwell A. Bertolero, William Liu, Mark D'Esposito
bioRxiv 056630; doi: https://doi.org/10.1101/056630
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The human thalamus is an integrative hub for functional brain networks
Kai Hwang, Maxwell A. Bertolero, William Liu, Mark D'Esposito
bioRxiv 056630; doi: https://doi.org/10.1101/056630

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