New Results
Genome-wide specificity profiles of CRISPR-Cas Cpf1 nucleases in human cells
Benjamin P. Kleinstiver, Shengdar Q. Tsai, Michelle S. Prew, Nhu T. Nguyen, Moira M. Welch, Jose M. Lopez, Zachary R. McCaw, Martin J. Aryee, J. Keiths Joung
doi: https://doi.org/10.1101/057802
Benjamin P. Kleinstiver
1Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129 USA
2Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 USA
3Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129 USA
4Department of Pathology, Harvard Medical School, Boston, MA 02115 USA
Shengdar Q. Tsai
1Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129 USA
2Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 USA
3Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129 USA
4Department of Pathology, Harvard Medical School, Boston, MA 02115 USA
Michelle S. Prew
1Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129 USA
2Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 USA
3Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129 USA
Nhu T. Nguyen
1Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129 USA
2Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 USA
3Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129 USA
Moira M. Welch
1Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129 USA
2Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 USA
3Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129 USA
Jose M. Lopez
1Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129 USA
2Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 USA
3Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129 USA
4Department of Pathology, Harvard Medical School, Boston, MA 02115 USA
Zachary R. McCaw
1Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129 USA
2Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 USA
5Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA
Martin J. Aryee
1Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129 USA
2Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 USA
4Department of Pathology, Harvard Medical School, Boston, MA 02115 USA
5Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA
J. Keiths Joung
1Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129 USA
2Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 USA
3Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129 USA
4Department of Pathology, Harvard Medical School, Boston, MA 02115 USA


You do not have access to the full text of this article, the first page of the PDF of this article appears above.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted June 09, 2016.
Genome-wide specificity profiles of CRISPR-Cas Cpf1 nucleases in human cells
Benjamin P. Kleinstiver, Shengdar Q. Tsai, Michelle S. Prew, Nhu T. Nguyen, Moira M. Welch, Jose M. Lopez, Zachary R. McCaw, Martin J. Aryee, J. Keiths Joung
bioRxiv 057802; doi: https://doi.org/10.1101/057802
Subject Area
Subject Areas
- Biochemistry (9568)
- Bioengineering (7080)
- Bioinformatics (24814)
- Biophysics (12594)
- Cancer Biology (9940)
- Cell Biology (14318)
- Clinical Trials (138)
- Developmental Biology (7940)
- Ecology (12090)
- Epidemiology (2067)
- Evolutionary Biology (15971)
- Genetics (10911)
- Genomics (14721)
- Immunology (9856)
- Microbiology (23611)
- Molecular Biology (9468)
- Neuroscience (50791)
- Paleontology (369)
- Pathology (1537)
- Pharmacology and Toxicology (2677)
- Physiology (4004)
- Plant Biology (8651)
- Synthetic Biology (2388)
- Systems Biology (6419)
- Zoology (1345)