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Identification of Novel and Differentially Expressed MicroRNAs in Goat Enzootic Nasal Adenocarcinoma

Bin Wang, Ni Ye, San-jie Cao, Xin-tian Wen, Yongxs Huang, Qi-gui Yan
doi: https://doi.org/10.1101/057885
Bin Wang
1College of Veterinary Medicine, Sichuan Agricultural University, Xin kang Road 46 Ya’ an, Sichuan 625000, P. R. China
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Ni Ye
1College of Veterinary Medicine, Sichuan Agricultural University, Xin kang Road 46 Ya’ an, Sichuan 625000, P. R. China
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San-jie Cao
1College of Veterinary Medicine, Sichuan Agricultural University, Xin kang Road 46 Ya’ an, Sichuan 625000, P. R. China
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Xin-tian Wen
1College of Veterinary Medicine, Sichuan Agricultural University, Xin kang Road 46 Ya’ an, Sichuan 625000, P. R. China
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Yongxs Huang
1College of Veterinary Medicine, Sichuan Agricultural University, Xin kang Road 46 Ya’ an, Sichuan 625000, P. R. China
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Qi-gui Yan
1College of Veterinary Medicine, Sichuan Agricultural University, Xin kang Road 46 Ya’ an, Sichuan 625000, P. R. China
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  • For correspondence: yanqigui@126.com.
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Abstract

Enzootic nasal adenocarcinoma (ENA), an epithelial tumor induced in goats and sheep by enzootic nasal tumor virus (ENTV), is a chronic, progressive,contact transmitted disease. This study aimed to identify novel and differentially expressed miRNAs in the tumor and para-carcinoma nasal tissuesofNanjiang yellow goats with ENA. Small RNA Illumina high-throughput sequencing was used to construct a goat nasal miRNA library.

406 known miRNAs and 29 novel miRNAs were identified. A total of 116 miRNAs were significantly differentially expressed in para-carcinoma nasal tissues and ENA; Target gene prediction and functional analysis revealed that 6176 non-redundancy target genes, 1792 significant GO and 97 significant KEGG pathway for 121 miRNAs were predicted.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 08, 2016.
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Identification of Novel and Differentially Expressed MicroRNAs in Goat Enzootic Nasal Adenocarcinoma
Bin Wang, Ni Ye, San-jie Cao, Xin-tian Wen, Yongxs Huang, Qi-gui Yan
bioRxiv 057885; doi: https://doi.org/10.1101/057885
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Identification of Novel and Differentially Expressed MicroRNAs in Goat Enzootic Nasal Adenocarcinoma
Bin Wang, Ni Ye, San-jie Cao, Xin-tian Wen, Yongxs Huang, Qi-gui Yan
bioRxiv 057885; doi: https://doi.org/10.1101/057885

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