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Long-term, layer-specific reverberant activity in the mouse somatosensory cortex following sensory stimulation

Elena Phoka, Aleksandra Berditchevskaia, Mauricio Barahona, View ORCID ProfileSimon R Schultz
doi: https://doi.org/10.1101/058958
Elena Phoka
aDepartment of Bioengineering, Imperial College London, SW7 2BP, London, UK
bDepartment of Mathematics, Imperial College London, SW7 2RH, London, UK
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Aleksandra Berditchevskaia
aDepartment of Bioengineering, Imperial College London, SW7 2BP, London, UK
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Mauricio Barahona
bDepartment of Mathematics, Imperial College London, SW7 2RH, London, UK
cCentre for Neurotechnology, Imperial College London, SW7 2BP, London, UK
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Simon R Schultz
aDepartment of Bioengineering, Imperial College London, SW7 2BP, London, UK
cCentre for Neurotechnology, Imperial College London, SW7 2BP, London, UK
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  • ORCID record for Simon R Schultz
  • For correspondence: s.schultz@imperial.ac.uk
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Abstract

Neocortical circuits exhibit spontaneous neuronal activity whose functional relevance remains enigmatic. Several proposed functions assume that sensory experience can influence subsequent spontaneous activity. However, long-term alterations in spontaneous firing rates following sensory stimulation have not been reported until now. Here we show that multi-whisker, spatiotemporally rich stimulation of mouse vibrissae induces a laminar-specific, long-term increase of spontaneous activity in the somatosensory cortex. Such stimulation additionally produces stereotypical neural ensemble firing patterns from simultaneously recorded single neurons, which are maintained during spontaneous activity following stimulus offset. The increased neural activity and concomitant ensemble firing patterns are sustained for at least 25 minutes after stimulation, and specific to layers IV and Vb. In contrast, the same stimulation protocol applied to a single whisker fails to elicit this effect. Since layer Vb has the largest receptive fields and, together with layer IV, receives direct thalamic and lateral drive, the increase in firing activity could be the result of mechanisms involving the integration of spatiotemporal patterns across multiple whiskers. Our results provide direct evidence of modification of spontaneous cortical activity by sensory stimulation and could offer insight into the role of spatiotemporal integration in memory storage mechanisms for complex stimuli.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted April 07, 2017.
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Long-term, layer-specific reverberant activity in the mouse somatosensory cortex following sensory stimulation
Elena Phoka, Aleksandra Berditchevskaia, Mauricio Barahona, Simon R Schultz
bioRxiv 058958; doi: https://doi.org/10.1101/058958
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Long-term, layer-specific reverberant activity in the mouse somatosensory cortex following sensory stimulation
Elena Phoka, Aleksandra Berditchevskaia, Mauricio Barahona, Simon R Schultz
bioRxiv 058958; doi: https://doi.org/10.1101/058958

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