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A genomic view of the peopling of the americas

View ORCID ProfilePontus Skoglund, David Reich
doi: https://doi.org/10.1101/058966
Pontus Skoglund
1Harvard Medical School, Boston, MA, USA
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Department of Archaeology and Classical History, Stockholm, Sweden
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David Reich
1Harvard Medical School, Boston, MA, USA
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
4Howard Hughes Medical Institute, Boston, MA, USA
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Abstract

Whole-genome studies have documented that most Native American ancestry stems from a single population that diversified within the continent more than twelve thousand years ago. However, this shared ancestry hides a more complex history whereby at least four distinct streams of Eurasian migration have contributed to present-day and prehistoric Native American populations. Whole genome studies enhanced by technological breakthroughs in ancient DNA now provide evidence of a sequence of events involving initial migration from a structured Northeast Asian source population, followed by a divergence into northern and southern Native American lineages. During the Holocene, new migrations from Asia introduced the Saqqaq/Dorset Paleoeskimo population to the North American Arctic ~4,500 years ago, ancestry that is potentially connected with ancestry found in Athabaskan-speakers today. This was then followed by a major new population turnover in the high Arctic involving Thule-related peoples who are the ancestors of present-day Inuit. We highlight several open questions that could be addressed through future genomic research.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted June 15, 2016.
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A genomic view of the peopling of the americas
Pontus Skoglund, David Reich
bioRxiv 058966; doi: https://doi.org/10.1101/058966
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A genomic view of the peopling of the americas
Pontus Skoglund, David Reich
bioRxiv 058966; doi: https://doi.org/10.1101/058966

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