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Gamma-rhythmic Gain Modulation

Jianguang Ni, Thomas Wunderle, Christopher M. Lewis, Robert Desimone, Ilka Diester, View ORCID ProfilePascal Fries
doi: https://doi.org/10.1101/060582
Jianguang Ni
Ernst Strungmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society;
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Thomas Wunderle
Ernst Strungmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society;
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Christopher M. Lewis
Ernst Strungmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society;
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Robert Desimone
Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, MIT
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Ilka Diester
Ernst Strungmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society;
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Pascal Fries
Ernst Strungmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society;
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  • ORCID record for Pascal Fries
  • For correspondence: pascal.fries@esi-frankfurt.de
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Abstract

Cognition requires the dynamic modulation of effective connectivity, i.e. the modulation of the postsynaptic neuronal response to a given input. If postsynaptic neurons are rhythmically active, this might entail rhythmic gain modulation, such that inputs synchronized to phases of high gain benefit from enhanced effective connectivity. We show that visually induced gamma-band activity in awake macaque area V4 rhythmically modulates responses to unpredictable stimulus events. This modulation exceeded a simple additive superposition of a constant response onto ongoing gamma-rhythmic firing, demonstrating the modulation of multiplicative gain. Gamma phases leading to strongest neuronal responses also led to shortest behavioral reaction times, suggesting functional relevance of the effect. Furthermore, we find that constant optogenetic stimulation of anesthetized cat area 21a produces gamma-band activity entailing a similar gain modulation. As the gamma rhythm in area 21a did not spread backwards to area 17, this suggests that postsynaptic gamma is sufficient for gain modulation.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted June 24, 2016.
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Gamma-rhythmic Gain Modulation
Jianguang Ni, Thomas Wunderle, Christopher M. Lewis, Robert Desimone, Ilka Diester, Pascal Fries
bioRxiv 060582; doi: https://doi.org/10.1101/060582
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Gamma-rhythmic Gain Modulation
Jianguang Ni, Thomas Wunderle, Christopher M. Lewis, Robert Desimone, Ilka Diester, Pascal Fries
bioRxiv 060582; doi: https://doi.org/10.1101/060582

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