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Detecting Genome-wide Variants of Eurasian Facial Shape Differentiation: DNA based Face Prediction Tested in Forensic Scenario

Lu Qiao, Yajun Yang, Pengcheng Fu, Sile Hu, Hang Zhou, Jingze Tan, Yan Lu, Haiyi Lou, Dongsheng Lu, Sijie Wu, Jing Guo, Shouneng Peng, Li Jin, Yaqun Guan, Sijia Wang, Shuhua Xu, Kun Tang
doi: https://doi.org/10.1101/062950
Lu Qiao
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
2University of Chinese Academy of Sciences, Beijing 100049, China;
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Yajun Yang
3State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China;
4Fudan-Taizhou Institute of Health Sciences, 1 Yaocheng Road, Taizhou, Jiangsu 225300, China;
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Pengcheng Fu
5Department of neurology, the First People’s Hospital of Chenzhou, Hunan, 423000, China;
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Sile Hu
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
2University of Chinese Academy of Sciences, Beijing 100049, China;
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Hang Zhou
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
2University of Chinese Academy of Sciences, Beijing 100049, China;
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Jingze Tan
3State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China;
4Fudan-Taizhou Institute of Health Sciences, 1 Yaocheng Road, Taizhou, Jiangsu 225300, China;
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Yan Lu
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
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Haiyi Lou
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
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Dongsheng Lu
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
2University of Chinese Academy of Sciences, Beijing 100049, China;
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Sijie Wu
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
2University of Chinese Academy of Sciences, Beijing 100049, China;
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Jing Guo
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
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Shouneng Peng
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
2University of Chinese Academy of Sciences, Beijing 100049, China;
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Li Jin
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
2University of Chinese Academy of Sciences, Beijing 100049, China;
3State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China;
4Fudan-Taizhou Institute of Health Sciences, 1 Yaocheng Road, Taizhou, Jiangsu 225300, China;
7Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China;
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Yaqun Guan
6Department of Biochemistry and Molecular Biology, Preclinical Medicine College, Xinjiang Medical University, Urumqi 830011, P. R China;
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Sijia Wang
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
2University of Chinese Academy of Sciences, Beijing 100049, China;
7Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China;
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  • For correspondence: tangkun@picb.ac.cn xushua@picb.ac.cn wangsijia@picb.ac.cn
Shuhua Xu
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
2University of Chinese Academy of Sciences, Beijing 100049, China;
7Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China;
8School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China.
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  • For correspondence: tangkun@picb.ac.cn xushua@picb.ac.cn wangsijia@picb.ac.cn
Kun Tang
1Chinese Academy of Sciences (CAS) Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China;
2University of Chinese Academy of Sciences, Beijing 100049, China;
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  • For correspondence: tangkun@picb.ac.cn xushua@picb.ac.cn wangsijia@picb.ac.cn
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Abstract

It is a long standing question as which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial trait variations were analyzed based on high dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inner-landmarks to dense shape geometrics. A series of genome-wide association analyses were conducted on a discovery panel of Uyghurs. Six significant loci were identified and four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in two independent cohorts of Uyghurs or Southern Han Chinese. We further developed a quantitative model to predict 3D faces based on 277 top GWAS SNPs. In hypothetic forensic scenarios, this model was found to significantly enhance the rate of suspect verification, suggesting a practical potential of related research.

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Posted July 12, 2016.
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Detecting Genome-wide Variants of Eurasian Facial Shape Differentiation: DNA based Face Prediction Tested in Forensic Scenario
Lu Qiao, Yajun Yang, Pengcheng Fu, Sile Hu, Hang Zhou, Jingze Tan, Yan Lu, Haiyi Lou, Dongsheng Lu, Sijie Wu, Jing Guo, Shouneng Peng, Li Jin, Yaqun Guan, Sijia Wang, Shuhua Xu, Kun Tang
bioRxiv 062950; doi: https://doi.org/10.1101/062950
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Detecting Genome-wide Variants of Eurasian Facial Shape Differentiation: DNA based Face Prediction Tested in Forensic Scenario
Lu Qiao, Yajun Yang, Pengcheng Fu, Sile Hu, Hang Zhou, Jingze Tan, Yan Lu, Haiyi Lou, Dongsheng Lu, Sijie Wu, Jing Guo, Shouneng Peng, Li Jin, Yaqun Guan, Sijia Wang, Shuhua Xu, Kun Tang
bioRxiv 062950; doi: https://doi.org/10.1101/062950

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