Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Origins of pandemic Vibrio cholerae from environmental gene pools

View ORCID ProfileB. Jesse Shapiro, Inès Levade, Gabriela Kovacikova, Ronald K. Taylor, View ORCID ProfileSalvador Almagro-Moreno
doi: https://doi.org/10.1101/063115
B. Jesse Shapiro
1Department of Biological Sciences, University of Montreal, Montreal, Quebec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Jesse Shapiro
Inès Levade
1Department of Biological Sciences, University of Montreal, Montreal, Quebec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gabriela Kovacikova
2Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ronald K. Taylor
2Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Salvador Almagro-Moreno
2Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, USA
3Burnett School of Biomedical Sciences, College of Medicine University of Central Florida, Orlando, Florida, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Salvador Almagro-Moreno
  • For correspondence: samoreno@ucf.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Some microbes can transition from an environmental lifestyle to a pathogenic one1–3. This ecological switch typically occurs through the acquisition of horizontally acquired virulence genes4,5. However, the genomic features that must be present in a population prior to the acquisition of virulence genes and emergence of pathogenic clones remain unknown. We hypothesized that virulence adaptive polymorphisms (VAPs) circulate in environmental populations and are required for this transition. We developed a comparative genomic framework for identifying VAPs, using Vibrio cholerae as a model. We then characterized several environmental VAP alleles to show that, while some of them reduced the ability of clinical strains to colonize a mammalian host, other alleles conferred efficient host colonization. These results show that VAPs are present in environmental bacterial populations prior to the emergence of virulent clones. We propose a scenario in which VAPs circulate in the environment, they become selected and enriched under certain ecologicalconditions, and finally a genomic background containing several VAPs acquires virulence factors that allows for its emergence as a pathogenic clone.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted December 13, 2016.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Origins of pandemic Vibrio cholerae from environmental gene pools
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Origins of pandemic Vibrio cholerae from environmental gene pools
B. Jesse Shapiro, Inès Levade, Gabriela Kovacikova, Ronald K. Taylor, Salvador Almagro-Moreno
bioRxiv 063115; doi: https://doi.org/10.1101/063115
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Origins of pandemic Vibrio cholerae from environmental gene pools
B. Jesse Shapiro, Inès Levade, Gabriela Kovacikova, Ronald K. Taylor, Salvador Almagro-Moreno
bioRxiv 063115; doi: https://doi.org/10.1101/063115

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Microbiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4113)
  • Biochemistry (8815)
  • Bioengineering (6518)
  • Bioinformatics (23459)
  • Biophysics (11789)
  • Cancer Biology (9207)
  • Cell Biology (13322)
  • Clinical Trials (138)
  • Developmental Biology (7436)
  • Ecology (11409)
  • Epidemiology (2066)
  • Evolutionary Biology (15149)
  • Genetics (10436)
  • Genomics (14043)
  • Immunology (9171)
  • Microbiology (22153)
  • Molecular Biology (8812)
  • Neuroscience (47566)
  • Paleontology (350)
  • Pathology (1428)
  • Pharmacology and Toxicology (2491)
  • Physiology (3730)
  • Plant Biology (8079)
  • Scientific Communication and Education (1437)
  • Synthetic Biology (2220)
  • Systems Biology (6037)
  • Zoology (1253)