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Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells

View ORCID ProfileYuwei Cui, Yanbin V. Wang, Silvia J. H. Park, View ORCID ProfileJonathan B. Demb, View ORCID ProfileDaniel A. Butts
doi: https://doi.org/10.1101/064592
Yuwei Cui
1 Dept. of Biology and Program in Neuroscience and Cognitive Science, University of Maryland, College Park 20742 USA
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Yanbin V. Wang
2 Dept. of Ophthalmology and Visual Science and Dept. of Cellular and Molecular Physiology, Yale University, New Haven, CT 06511 USA
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Silvia J. H. Park
2 Dept. of Ophthalmology and Visual Science and Dept. of Cellular and Molecular Physiology, Yale University, New Haven, CT 06511 USA
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Jonathan B. Demb
2 Dept. of Ophthalmology and Visual Science and Dept. of Cellular and Molecular Physiology, Yale University, New Haven, CT 06511 USA
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Daniel A. Butts
1 Dept. of Biology and Program in Neuroscience and Cognitive Science, University of Maryland, College Park 20742 USA
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Abstract

Visual processing depends on specific computations implemented by complex neural circuits. Here, we present a circuit-inspired model of retinal ganglion cell computation, targeted to explain their temporal dynamics and adaptation to contrast. To localize the sources of such processing, we used recordings at the levels of synaptic input and spiking output in the in vitro mouse retina. We found that an ON-Alpha ganglion cell’s excitatory synaptic inputs were described by a divisive interaction between excitation and delayed suppression, which explained nonlinear processing already present in ganglion cell inputs. Ganglion cell output was further shaped by spike generation mechanisms. The full model accurately predicted spike responses with unprecedented millisecond precision, and accurately described contrast adaption of the spike train. These results demonstrate how circuit and cell-intrinsic mechanisms interact for ganglion cell function and, more generally, illustrate the power of circuit-inspired modeling of sensory processing.

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Posted July 19, 2016.
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Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells
Yuwei Cui, Yanbin V. Wang, Silvia J. H. Park, Jonathan B. Demb, Daniel A. Butts
bioRxiv 064592; doi: https://doi.org/10.1101/064592
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Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells
Yuwei Cui, Yanbin V. Wang, Silvia J. H. Park, Jonathan B. Demb, Daniel A. Butts
bioRxiv 064592; doi: https://doi.org/10.1101/064592

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