The druggable genome and support for target identification and validation in drug development

Chris Finan; Anna Gaulton; Felix. A Kruger; Tom Lumbers; Tina Shah; Jorgen Engmann; Luana Galver; Ryan Kelley; Anneli Karlsson; Rita Santos; John P. Overington; Aroon D. Hingorani; Juan P. Casas

doi:10.1101/066027

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The druggable genome and support for target identification and validation in drug development

Chris Finan, Anna Gaulton, Felix. A Kruger, Tom Lumbers, Tina Shah, Jorgen Engmann, Luana Galver, Ryan Kelley, Anneli Karlsson, Rita Santos, John P. Overington, Aroon D. Hingorani, Juan P. Casas

doi: https://doi.org/10.1101/066027

Chris Finan

1Institute of Cardiovascular Science, Faculty of Population Health, University College London, London WC1E 6BT

3Farr Institute in London, Institute of Health Informatics, University College London, London WC1E 6BT

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Anna Gaulton

2European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom

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Felix. A Kruger

1Institute of Cardiovascular Science, Faculty of Population Health, University College London, London WC1E 6BT

3Farr Institute in London, Institute of Health Informatics, University College London, London WC1E 6BT

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Tom Lumbers

1Institute of Cardiovascular Science, Faculty of Population Health, University College London, London WC1E 6BT

3Farr Institute in London, Institute of Health Informatics, University College London, London WC1E 6BT

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Tina Shah

1Institute of Cardiovascular Science, Faculty of Population Health, University College London, London WC1E 6BT

3Farr Institute in London, Institute of Health Informatics, University College London, London WC1E 6BT

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Jorgen Engmann

1Institute of Cardiovascular Science, Faculty of Population Health, University College London, London WC1E 6BT

3Farr Institute in London, Institute of Health Informatics, University College London, London WC1E 6BT

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Luana Galver

5Illumina Inc, 5200 Illumina Way, San Diego, CA 92122 USA

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Ryan Kelley

5Illumina Inc, 5200 Illumina Way, San Diego, CA 92122 USA

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Anneli Karlsson

2European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom

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Rita Santos

2European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom

6GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, United Kingdom. (current address)

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John P. Overington

2European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom

4Stratified Medical, 40 Churchway, London, UK

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For correspondence: [email protected] [email protected] [email protected]

Aroon D. Hingorani

1Institute of Cardiovascular Science, Faculty of Population Health, University College London, London WC1E 6BT

3Farr Institute in London, Institute of Health Informatics, University College London, London WC1E 6BT

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For correspondence: [email protected] [email protected] [email protected]

Juan P. Casas

3Farr Institute in London, Institute of Health Informatics, University College London, London WC1E 6BT

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For correspondence: [email protected] [email protected] [email protected]

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Posted July 26, 2016.

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The druggable genome and support for target identification and validation in drug development

Chris Finan, Anna Gaulton, Felix. A Kruger, Tom Lumbers, Tina Shah, Jorgen Engmann, Luana Galver, Ryan Kelley, Anneli Karlsson, Rita Santos, John P. Overington, Aroon D. Hingorani, Juan P. Casas

bioRxiv 066027; doi: https://doi.org/10.1101/066027

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The druggable genome and support for target identification and validation in drug development

Chris Finan, Anna Gaulton, Felix. A Kruger, Tom Lumbers, Tina Shah, Jorgen Engmann, Luana Galver, Ryan Kelley, Anneli Karlsson, Rita Santos, John P. Overington, Aroon D. Hingorani, Juan P. Casas

bioRxiv 066027; doi: https://doi.org/10.1101/066027

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