Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records

Fernanda Polubriaginof; Rami Vanguri; Kayla Quinnies; Gillian M. Belbin; Alexandre Yahi; Hojjat Salmasian; Tal Lorberbaum; Victor Nwankwo; Li Li; Mark Shervey; Patricia Glowe; Iuliana Ionita-Laza; Mary Simmerling; George Hripcsak; Suzanne Bakken; David Goldstein; Krzysztof Kiryluk; Eimear E. Kenny; Joel Dudley; David K. Vawdrey; Nicholas P. Tatonetti

doi:10.1101/066068

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Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records

View ORCID ProfileFernanda Polubriaginof, Rami Vanguri, Kayla Quinnies, Gillian M. Belbin, Alexandre Yahi, Hojjat Salmasian, Tal Lorberbaum, Victor Nwankwo, Li Li, Mark Shervey, Patricia Glowe, Iuliana Ionita-Laza, Mary Simmerling, George Hripcsak, Suzanne Bakken, David Goldstein, Krzysztof Kiryluk, Eimear E. Kenny, Joel Dudley, David K. Vawdrey, View ORCID ProfileNicholas P. Tatonetti

doi: https://doi.org/10.1101/066068

Fernanda Polubriaginof

1Department of Biomedical Informatics, Columbia University, New York, NY

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Rami Vanguri

1Department of Biomedical Informatics, Columbia University, New York, NY

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Kayla Quinnies

1Department of Biomedical Informatics, Columbia University, New York, NY

2Institute for Genomic Medicine, Columbia University, New York, NY

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Gillian M. Belbin

3Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

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Alexandre Yahi

1Department of Biomedical Informatics, Columbia University, New York, NY

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Hojjat Salmasian

1Department of Biomedical Informatics, Columbia University, New York, NY

4Value Institute, NewYork-Presbyterian Hospital, New York, NY

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Tal Lorberbaum

1Department of Biomedical Informatics, Columbia University, New York, NY

5Department of Physiology and Cellular Biophysics, Columbia University, New York, NY

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Victor Nwankwo

1Department of Biomedical Informatics, Columbia University, New York, NY

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Li Li

3Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

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Mark Shervey

3Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

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Patricia Glowe

3Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

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Iuliana Ionita-Laza

6Mailman School of Public Health, Columbia University, New York, NY

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Mary Simmerling

7Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY

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George Hripcsak

1Department of Biomedical Informatics, Columbia University, New York, NY

8Medical Informatics Services, NewYork-Presbyterian Hospital, New York, NY

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Suzanne Bakken

1Department of Biomedical Informatics, Columbia University, New York, NY

9School of Nursing, Columbia University, New York, NY

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David Goldstein

2Institute for Genomic Medicine, Columbia University, New York, NY

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Krzysztof Kiryluk

10Department of Medicine, Columbia University, New York, NY

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Eimear E. Kenny

3Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

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Joel Dudley

3Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

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David K. Vawdrey

1Department of Biomedical Informatics, Columbia University, New York, NY

4Value Institute, NewYork-Presbyterian Hospital, New York, NY

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Nicholas P. Tatonetti

1Department of Biomedical Informatics, Columbia University, New York, NY

2Institute for Genomic Medicine, Columbia University, New York, NY

10Department of Medicine, Columbia University, New York, NY

11Department of Systems Biology, Columbia University, New York, NY

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ORCID record for Nicholas P. Tatonetti
For correspondence: nick.tatonetti@columbia.edu

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Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records

Fernanda Polubriaginof, Rami Vanguri, Kayla Quinnies, Gillian M. Belbin, Alexandre Yahi, Hojjat Salmasian, Tal Lorberbaum, Victor Nwankwo, Li Li, Mark Shervey, Patricia Glowe, Iuliana Ionita-Laza, Mary Simmerling, George Hripcsak, Suzanne Bakken, David Goldstein, Krzysztof Kiryluk, Eimear E. Kenny, Joel Dudley, David K. Vawdrey, Nicholas P. Tatonetti

bioRxiv 066068; doi: https://doi.org/10.1101/066068

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