Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records

Fernanda Polubriaginof; Rami Vanguri; Kayla Quinnies; Gillian M. Belbin; Alexandre Yahi; Hojjat Salmasian; Tal Lorberbaum; Victor Nwankwo; Li Li; Mark Shervey; Patricia Glowe; Iuliana Ionita-Laza; Mary Simmerling; George Hripcsak; Suzanne Bakken; David Goldstein; Krzysztof Kiryluk; Eimear E. Kenny; Joel Dudley; David K. Vawdrey; Nicholas P. Tatonetti

doi:10.1101/066068

New Results

Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records

View ORCID ProfileFernanda Polubriaginof, Rami Vanguri, Kayla Quinnies, Gillian M. Belbin, Alexandre Yahi, Hojjat Salmasian, Tal Lorberbaum, Victor Nwankwo, Li Li, Mark Shervey, Patricia Glowe, Iuliana Ionita-Laza, Mary Simmerling, George Hripcsak, Suzanne Bakken, David Goldstein, Krzysztof Kiryluk, Eimear E. Kenny, Joel Dudley, David K. Vawdrey, View ORCID ProfileNicholas P. Tatonetti

doi: https://doi.org/10.1101/066068

Fernanda Polubriaginof

Department of Biomedical Informatics, Columbia University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Fernanda Polubriaginof

Rami Vanguri

Department of Biomedical Informatics, Columbia University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kayla Quinnies

Department of Biomedical Informatics, Columbia University, New York, NYInstitute for Genomic Medicine, Columbia University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gillian M. Belbin

Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alexandre Yahi

Department of Biomedical Informatics, Columbia University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Hojjat Salmasian

Department of Biomedical Informatics, Columbia University, New York, NYValue Institute, NewYork-Presbyterian Hospital, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tal Lorberbaum

Department of Biomedical Informatics, Columbia University, New York, NYDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Victor Nwankwo

Department of Biomedical Informatics, Columbia University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Li Li

Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mark Shervey

Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Patricia Glowe

Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Iuliana Ionita-Laza

Mailman School of Public Health, Columbia University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mary Simmerling

Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

George Hripcsak

Department of Biomedical Informatics, Columbia University, New York, NYMedical Informatics Services, NewYork-Presbyterian Hospital, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Suzanne Bakken

Department of Biomedical Informatics, Columbia University, New York, NYSchool of Nursing, Columbia University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

David Goldstein

Institute for Genomic Medicine, Columbia University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Krzysztof Kiryluk

Department of Medicine, Columbia University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Eimear E. Kenny

Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Joel Dudley

Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

David K. Vawdrey

Department of Biomedical Informatics, Columbia University, New York, NYValue Institute, NewYork-Presbyterian Hospital, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nicholas P. Tatonetti

Department of Biomedical Informatics, Columbia University, New York, NYInstitute for Genomic Medicine, Columbia University, New York, NYDepartment of Medicine, Columbia University, New York, NYDepartment of Systems Biology, Columbia University, New York, NY

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Nicholas P. Tatonetti
For correspondence: nick.tatonetti@columbia.edu

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Article usage

Article usage: July 2016 to June 2019

	Abstract	Full	Pdf
Jul 2016	1846	0	358
Aug 2016	967	0	403
Sep 2016	179	0	77
Oct 2016	479	0	191
Nov 2016	228	0	102
Dec 2016	71	0	51
Jan 2017	92	0	73
Feb 2017	92	0	50
Mar 2017	137	0	133
Apr 2017	89	0	57
May 2017	559	0	183
Jun 2017	144	0	96
Jul 2017	111	0	66
Aug 2017	65	0	38
Sep 2017	239	0	47
Oct 2017	98	0	31
Nov 2017	116	0	30
Dec 2017	79	0	31
Jan 2018	111	0	31
Feb 2018	115	0	39
Mar 2018	900	0	248
Apr 2018	236	0	88
May 2018	351	0	100
Jun 2018	239	0	84
Jul 2018	131	0	37
Aug 2018	107	0	25
Sep 2018	234	0	45
Oct 2018	90	0	26
Nov 2018	117	0	33
Dec 2018	107	0	27
Jan 2019	154	0	30
Feb 2019	93	0	28
Mar 2019	120	7	75
Apr 2019	56	5	30
May 2019	57	9	18
Jun 2019	45	6	7

View the discussion thread.

Posted May 24, 2017.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records

Fernanda Polubriaginof, Rami Vanguri, Kayla Quinnies, Gillian M. Belbin, Alexandre Yahi, Hojjat Salmasian, Tal Lorberbaum, Victor Nwankwo, Li Li, Mark Shervey, Patricia Glowe, Iuliana Ionita-Laza, Mary Simmerling, George Hripcsak, Suzanne Bakken, David Goldstein, Krzysztof Kiryluk, Eimear E. Kenny, Joel Dudley, David K. Vawdrey, Nicholas P. Tatonetti

bioRxiv 066068; doi: https://doi.org/10.1101/066068

Share This Article: