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Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pairs

Sezen Vatansever, Zeynep H. Gümüş, Burak Erman
doi: https://doi.org/10.1101/067496
Sezen Vatansever
1Department of Chemical and Biological Engineering, College of Engineering, Koç University, Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, Turkey
2Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029
3Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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Zeynep H. Gümüş
2Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029
3Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029
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  • For correspondence: berman@ku.edu.tr zeynep.gumus@mssm.edu
Burak Erman
1Department of Chemical and Biological Engineering, College of Engineering, Koç University, Rumelifeneri Yolu, 34450, Sarıyer, Istanbul, Turkey
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  • For correspondence: berman@ku.edu.tr zeynep.gumus@mssm.edu
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Summary

While mutant K-Ras is an important therapeutic target for human cancers, there are still no drugs that directly target it. Recent promising studies emphasize the significance of dynamics data to selectively target its active/inactive states. However, despite tremendous information on K-Ras, the direction of information flow in the allosteric regulation of its dynamics has not yet been elucidated. Here, we present a novel approach that identifies causality in correlated motions of proteins and apply it to K-Ras dynamics. Specifically, we analyze molecular dynamics simulations data and comprehensively investigate nucleotide-dependent intrinsic K-Ras activity. We show that GTP binding leads to characteristic residue correlations with relatively long decay times by stabilizing K-Ras motions. Furthermore, we identify for the first time driver-follower relationships of correlated motions in the regulation of K-Ras activity. Our results can be utilized for directly targeting mutant K-Ras in future studies.

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Posted August 02, 2016.
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Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pairs
Sezen Vatansever, Zeynep H. Gümüş, Burak Erman
bioRxiv 067496; doi: https://doi.org/10.1101/067496
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Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pairs
Sezen Vatansever, Zeynep H. Gümüş, Burak Erman
bioRxiv 067496; doi: https://doi.org/10.1101/067496

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