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Interactive online brain shape visualization

View ORCID ProfileAnisha Keshavan, View ORCID ProfileArno Klein, View ORCID ProfileBen Cipollini
doi: https://doi.org/10.1101/067678
Anisha Keshavan
1The UC Berkeley – UCSF Graduate Program in Bioengineering, Berkeley, 306 Stanley Hall, 94720, California, USA
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  • For correspondence: keshavan@berkeley.edu
Arno Klein
2Sage Bionetworks, Seattle, 1100 Fairview Avenue North, M1-C108, 98109, Washington, USA
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Ben Cipollini
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Abstract

Urbanization presents unique environmental challenges to human commensal species. The Afrotropical Anopheles gambiae complex contains a number of synanthropic mosquito species that are major vectors of malaria. To examine ongoing cryptic diversification within the complex, we performed reduced representation sequencing on 941 mosquitoes collected across four ecogeographic zones in Cameroon. We find evidence for clear subdivision within An. coluzzii and An. gambiae s.s. - the two most significant malaria vectors in the region. Importantly, in both species rural and urban populations of mosquitoes were genetically differentiated. Genome scans of cryptic subgroups reveal pervasive signatures of selection centered on genes involved in xenobiotic resistance. Notably, a selective sweep containing eight detoxification enzymes is unique to urban mosquitoes that exploit polluted breeding sites. Overall, our study reveals that anthropogenic environmental modification is driving population differentiation and local adaptation in African malaria mosquitoes with potentially significant consequences for malaria epidemiology.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted August 05, 2016.
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Interactive online brain shape visualization
Anisha Keshavan, Arno Klein, Ben Cipollini
bioRxiv 067678; doi: https://doi.org/10.1101/067678
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Interactive online brain shape visualization
Anisha Keshavan, Arno Klein, Ben Cipollini
bioRxiv 067678; doi: https://doi.org/10.1101/067678

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