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Reward learning deficits in Parkinson’s disease depend on depression

Monique H.M. Timmer, Guillaume Sescousse, Marieke E. van der Schaaf, Rianne A.J. Esselink, Roshan Cools
doi: https://doi.org/10.1101/069062
Monique H.M. Timmer
1Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, 6500 HB Nijmegen, the Netherlands
2Radboud university medical center, Department of Neurology and Parkinson Center Nijmegen (ParC), 6500 HB Nijmegen, the Netherlands
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Guillaume Sescousse
1Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, 6500 HB Nijmegen, the Netherlands
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Marieke E. van der Schaaf
1Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, 6500 HB Nijmegen, the Netherlands
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Rianne A.J. Esselink
2Radboud university medical center, Department of Neurology and Parkinson Center Nijmegen (ParC), 6500 HB Nijmegen, the Netherlands
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Roshan Cools
1Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, 6500 HB Nijmegen, the Netherlands
3Radboud university medical center, Department of Psychiatry, 6500 HB Nijmegen, the Netherlands
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Abstract

Background Depression is one of the most common and debilitating non-motor symptoms of Parkinson’s disease (PD). The neurocognitive mechanisms underlying depression in PD are unclear and treatment is often suboptimal.

Methods We investigated the role of striatal dopamine in reversal learning from reward and punishment by combining a controlled medication withdrawal procedure with functional magnetic resonance imaging (fMRI) in 22 non-depressed PD patients and 19 PD patients with past or present PD-related depression.

Results PD patients with a PD-related depression (history) exhibited impaired reward versus punishment reversal learning as well as reduced reward versus punishment-related BOLD signal in the striatum (putamen) compared with non-depressed PD patients. No effects of dopaminergic medication were observed.

Conclusions The present findings demonstrate that impairments in reversal learning from reward versus punishment and associated reward-related striatal signalling depend on the presence of (a history of) depression in PD.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted August 12, 2016.
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Reward learning deficits in Parkinson’s disease depend on depression
Monique H.M. Timmer, Guillaume Sescousse, Marieke E. van der Schaaf, Rianne A.J. Esselink, Roshan Cools
bioRxiv 069062; doi: https://doi.org/10.1101/069062
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Reward learning deficits in Parkinson’s disease depend on depression
Monique H.M. Timmer, Guillaume Sescousse, Marieke E. van der Schaaf, Rianne A.J. Esselink, Roshan Cools
bioRxiv 069062; doi: https://doi.org/10.1101/069062

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