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Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli

View ORCID ProfileMichael G. Napolitano, Matthieu Landon, Christopher J. Gregg, Marc J. Lajoie, Lakshmi N. Govindarajan, Joshua A. Mosberg, Gleb Kuznetsov, Daniel B. Goodman, Oscar Vargas-Rodriguez, Farren J. Isaacs, Dieter Söll, George M. Church
doi: https://doi.org/10.1101/069385
Michael G. Napolitano
1Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115
‡Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115
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  • ORCID record for Michael G. Napolitano
Matthieu Landon
1Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115
2Systems Biology Graduate Program, Harvard Medical School, Boston, MA 02115
5Ecole des Mines de Paris, Mines Paristech, 75272 Paris, France
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Christopher J. Gregg
1Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115
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Marc J. Lajoie
1Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115
†Program in Chemical Biology, Harvard University, Cambridge, MA 02138
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Lakshmi N. Govindarajan
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Joshua A. Mosberg
1Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115
†Program in Chemical Biology, Harvard University, Cambridge, MA 02138
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Gleb Kuznetsov
1Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115
4Program in Biophysics, Harvard University, Boston, Massachusetts 02115, USA
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Daniel B. Goodman
1Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115
6Harvard-MIT Health Sciences and Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
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Oscar Vargas-Rodriguez
7Department of Molecular Biophysics and Biochemistry Yale University, New Haven, CT 06516, USA
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Farren J. Isaacs
3Molecular, Cellular, Developmental & Systems Biology Institute, Yale University, New Haven, CT 06516, USA
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Dieter Söll
7Department of Molecular Biophysics and Biochemistry Yale University, New Haven, CT 06516, USA
8Department of Chemistry Yale University, New Haven, CT 06516, USA
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George M. Church
1Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115
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Article Information

doi 
https://doi.org/10.1101/069385
History 
  • August 14, 2016.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Michael G. Napolitano*1,‡,
  2. Matthieu Landon*1,2,5,
  3. Christopher J. Gregg*1,
  4. Marc J. Lajoie*1,†,
  5. Lakshmi N. Govindarajan,
  6. Joshua A. Mosberg1,†,
  7. Gleb Kuznetsov1,4,
  8. Daniel B. Goodman1,6,
  9. Oscar Vargas-Rodriguez7,
  10. Farren J. Isaacs3,
  11. Dieter Söll7,8 and
  12. George M. Church1
  1. 1Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115
  2. †Program in Chemical Biology, Harvard University, Cambridge, MA 02138
  3. ‡Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115
  4. 2Systems Biology Graduate Program, Harvard Medical School, Boston, MA 02115
  5. 3Molecular, Cellular, Developmental & Systems Biology Institute, Yale University, New Haven, CT 06516, USA
  6. 4Program in Biophysics, Harvard University, Boston, Massachusetts 02115, USA
  7. 5Ecole des Mines de Paris, Mines Paristech, 75272 Paris, France
  8. 6Harvard-MIT Health Sciences and Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
  9. 7Department of Molecular Biophysics and Biochemistry Yale University, New Haven, CT 06516, USA
  10. 8Department of Chemistry Yale University, New Haven, CT 06516, USA
  1. Address correspondence to: Marc J Lajoie, 4000 15th Ave NE, Molecular Engineering and Sciences, Room 440, University of Washington, Seattle, WA 98195, Tel: 206-616-7542. Fax: 206-685-1792, mlajoie{at}uw.edu and George M Church, 77 Avenue Louis Pasteur, New Research Building, Room 238, Harvard Medical School, Boston, MA 02115, Tel: 617-432-1278. Fax: 617-432-6513, gchurch{at}genetics.med.harvard.edu
  1. ↵*The contributions of the first four authors are equal.

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Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli
Michael G. Napolitano, Matthieu Landon, Christopher J. Gregg, Marc J. Lajoie, Lakshmi N. Govindarajan, Joshua A. Mosberg, Gleb Kuznetsov, Daniel B. Goodman, Oscar Vargas-Rodriguez, Farren J. Isaacs, Dieter Söll, George M. Church
bioRxiv 069385; doi: https://doi.org/10.1101/069385
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Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli
Michael G. Napolitano, Matthieu Landon, Christopher J. Gregg, Marc J. Lajoie, Lakshmi N. Govindarajan, Joshua A. Mosberg, Gleb Kuznetsov, Daniel B. Goodman, Oscar Vargas-Rodriguez, Farren J. Isaacs, Dieter Söll, George M. Church
bioRxiv 069385; doi: https://doi.org/10.1101/069385

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