Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli

Michael G. Napolitano; Matthieu Landon; Christopher J. Gregg; Marc J. Lajoie; Lakshmi N. Govindarajan; Joshua A. Mosberg; Gleb Kuznetsov; Daniel B. Goodman; Oscar Vargas-Rodriguez; Farren J. Isaacs; Dieter Söll; George M. Church

doi:10.1101/069385

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Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli

View ORCID ProfileMichael G. Napolitano, Matthieu Landon, Christopher J. Gregg, Marc J. Lajoie, Lakshmi N. Govindarajan, Joshua A. Mosberg, Gleb Kuznetsov, Daniel B. Goodman, Oscar Vargas-Rodriguez, Farren J. Isaacs, Dieter Söll, George M. Church

doi: https://doi.org/10.1101/069385

Michael G. Napolitano

Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115

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ORCID record for Michael G. Napolitano

Matthieu Landon

Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115Systems Biology Graduate Program, Harvard Medical School, Boston, MA 02115Ecole des Mines de Paris, Mines Paristech, 75272 Paris, France

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Christopher J. Gregg

Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115

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Marc J. Lajoie

Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115Program in Chemical Biology, Harvard University, Cambridge, MA 02138

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Lakshmi N. Govindarajan

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Joshua A. Mosberg

Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115Program in Chemical Biology, Harvard University, Cambridge, MA 02138

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Gleb Kuznetsov

Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115Program in Biophysics, Harvard University, Boston, Massachusetts 02115, USA

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Daniel B. Goodman

Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115Harvard-MIT Health Sciences and Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

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Oscar Vargas-Rodriguez

Department of Molecular Biophysics and Biochemistry Yale University, New Haven, CT 06516, USA

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Farren J. Isaacs

Molecular, Cellular, Developmental & Systems Biology Institute, Yale University, New Haven, CT 06516, USA

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Dieter Söll

Department of Molecular Biophysics and Biochemistry Yale University, New Haven, CT 06516, USADepartment of Chemistry Yale University, New Haven, CT 06516, USA

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George M. Church

Department of Genetics & Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115

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Posted August 14, 2016.

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Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli

Michael G. Napolitano, Matthieu Landon, Christopher J. Gregg, Marc J. Lajoie, Lakshmi N. Govindarajan, Joshua A. Mosberg, Gleb Kuznetsov, Daniel B. Goodman, Oscar Vargas-Rodriguez, Farren J. Isaacs, Dieter Söll, George M. Church

bioRxiv 069385; doi: https://doi.org/10.1101/069385

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