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ResistoMap — online visualization of human gut microbiota antibiotic resistome

Konstantin Yarygin, Boris Kovarsky, Tatyana Bibikova, Damir Melnikov, Alexander Tyakht, Dmitry Alexeev
doi: https://doi.org/10.1101/070714
Konstantin Yarygin
1Federal Research and Clinical Centre of Physical-Chemical Medicine (FRCC CPM), Malaya Pirogovskaya 1a, Moscow 119435, Russia
2Moscow Institute of Physics and Technology, Institutsky lane 9, Dolgoprudny, Moscow Region, 141700, Russia
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Boris Kovarsky
1Federal Research and Clinical Centre of Physical-Chemical Medicine (FRCC CPM), Malaya Pirogovskaya 1a, Moscow 119435, Russia
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Tatyana Bibikova
3Data Laboratory, Moscow, Russia
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Damir Melnikov
3Data Laboratory, Moscow, Russia
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Alexander Tyakht
1Federal Research and Clinical Centre of Physical-Chemical Medicine (FRCC CPM), Malaya Pirogovskaya 1a, Moscow 119435, Russia
2Moscow Institute of Physics and Technology, Institutsky lane 9, Dolgoprudny, Moscow Region, 141700, Russia
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Dmitry Alexeev
1Federal Research and Clinical Centre of Physical-Chemical Medicine (FRCC CPM), Malaya Pirogovskaya 1a, Moscow 119435, Russia
2Moscow Institute of Physics and Technology, Institutsky lane 9, Dolgoprudny, Moscow Region, 141700, Russia
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Abstract

Summary We created ResistoMap — a Web-based interactive visualization of the presence of genetic determinants conferring resistance to antibiotics, biocides and heavy metals in human gut microbiota. ResistoMap displays the data about more than 1600 published gut metagenomes of the world populations including both healthy subjects and patients. Multiparameter display filters allow visual assessment of the associations between the meta-data and proportions of resistome. The geographic map navigation layer allows to state hypotheses regarding the global trends of antibiotic resistance and correlate the gut resistome variations with the national clinical guidelines on antibiotics application.

Availability and implementation ResistoMap is publicly available at http://resistomap.datalaboratory.ru

Footnotes

  • ↵* yarygin{at}phystech.edu

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted August 23, 2016.
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ResistoMap — online visualization of human gut microbiota antibiotic resistome
Konstantin Yarygin, Boris Kovarsky, Tatyana Bibikova, Damir Melnikov, Alexander Tyakht, Dmitry Alexeev
bioRxiv 070714; doi: https://doi.org/10.1101/070714
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ResistoMap — online visualization of human gut microbiota antibiotic resistome
Konstantin Yarygin, Boris Kovarsky, Tatyana Bibikova, Damir Melnikov, Alexander Tyakht, Dmitry Alexeev
bioRxiv 070714; doi: https://doi.org/10.1101/070714

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