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Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

View ORCID ProfileXueyi Shen, Lianne M. Reus, Simon R. Cox, Mark J. Adams, David C. Liewald, Mark E. Bastin, Daniel J. Smith, Ian J. Deary, Heather C. Whalley, Andrew M. McIntosh
doi: https://doi.org/10.1101/070912
Xueyi Shen
1Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
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  • For correspondence: s1517658@sms.ed.ac.uk
Lianne M. Reus
1Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
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Simon R. Cox
2Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
3Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
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Mark J. Adams
1Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
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David C. Liewald
3Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
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Mark E. Bastin
2Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
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Daniel J. Smith
4Institute of Health and Wellbeing, Mental Health and Wellbeing Research Group, University of Glasgow, Glasgow, United Kingdom
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Ian J. Deary
2Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
3Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
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Heather C. Whalley
1Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
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Andrew M. McIntosh
1Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
2Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
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Abstract

Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different diagnostic criteria, scanners and imaging sequences may, however, obscure further anatomical differences. In this study, we tested for differences in subcortical grey matter volume (n=1157) and white matter integrity (n=1089) between depressed individuals and controls in the subset of 8590 UK Biobank Imaging study participants who had undergone depression assessments. Whilst we found no significant differences in subcortical volumes, significant reductions were found in depressed individuals versus controls in global white matter integrity, as measured by fractional anisotropy (FA) (β=-0.182, p=0.005). We also found reductions in FA in association/commissural fibres (β=-0.184, pcorrected=0.010) and thalamic radiations (β=-0.159, pcorrected=0.020). Tract-specific FA reductions were also found in the left superior longitudinal fasciculus (β=-0.194, pcorrected=0.025), superior thalamic radiation (β=-0.224, pcorrected=0.009) and forceps major (β=-0.193, pcorrected=0.025) in depression (all betas standardised). Our findings provide further evidence for disrupted white matter integrity in MDD.

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Posted June 14, 2017.
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Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
Xueyi Shen, Lianne M. Reus, Simon R. Cox, Mark J. Adams, David C. Liewald, Mark E. Bastin, Daniel J. Smith, Ian J. Deary, Heather C. Whalley, Andrew M. McIntosh
bioRxiv 070912; doi: https://doi.org/10.1101/070912
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Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
Xueyi Shen, Lianne M. Reus, Simon R. Cox, Mark J. Adams, David C. Liewald, Mark E. Bastin, Daniel J. Smith, Ian J. Deary, Heather C. Whalley, Andrew M. McIntosh
bioRxiv 070912; doi: https://doi.org/10.1101/070912

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