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What the Success of Brain Imaging Implies about the Neural Code

View ORCID ProfileOlivia Guest, View ORCID ProfileBradley C. Love
doi: https://doi.org/10.1101/071076
Olivia Guest
University of Oxford
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Bradley C. Love
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Abstract

The success of fMRI places constraints on the nature of the neural code. The fact that researchers can infer similarities between neural representations, despite limitations in what fMRI measures, implies that certain neural coding schemes are more likely than others. For fMRI to be successful given its low temporal and spatial resolution, the neural code must be smooth at the sub-voxel and functional level such that similar stimuli engender similar internal representations. Through proof and simulation, we evaluate a number of reasonable coding schemes and demonstrate that only a subset are plausible given both fMRI’s successes and its limitations in measuring neural activity. Deep neural network approaches, which have been forwarded as computational accounts of the ventral stream, are consistent with the success of fMRI, though functional smoothness breaks down in the later network layers. These results have implications for the nature of neural code and ventral stream, as well as what can be successfully investigated with fMRI.

Footnotes

  • This work was supported by the Leverhulme Trust (Grant RPG- 2014-075), the NIH (Grant 1P01HD080679), and a Wellcome Trust Investigator Award (Grant WT106931MA) to BCL. Correspondences regarding this work can be sent to olivia.guest{at}psy.ox.ac.uk or b.love{at}ucl.ac.uk. The authors declare that they have no competing interests. The authors would like to thank Russ Poldrack, Tal Yarkoni, Niko Kriegeskorte, Sam Schwarzkopf, Christiane Ahlheim, and Johan Carlin for their thoughtful feedback on the preprint version, http://dx.doi.org/10.1101/071076. The code used to run these experiments is freely available, http://osf.io/v8baz

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted September 09, 2016.
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What the Success of Brain Imaging Implies about the Neural Code
Olivia Guest, Bradley C. Love
bioRxiv 071076; doi: https://doi.org/10.1101/071076
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What the Success of Brain Imaging Implies about the Neural Code
Olivia Guest, Bradley C. Love
bioRxiv 071076; doi: https://doi.org/10.1101/071076

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