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The impacts of drift and selection on genomic evolution in holometabolous insects

K. Jun Tong, Sebastián Duchêne, Nathan Lo, Simon Y. W. Ho
doi: https://doi.org/10.1101/072512
K. Jun Tong
1School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia
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  • For correspondence: jun.tong@sydney.edu.au
Sebastián Duchêne
1School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia
2Marie Bashir Institute for Infectious Diseases & Biosecurity, University of Sydney, Sydney, NSW 2006, Australia
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Nathan Lo
1School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia
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Simon Y. W. Ho
1School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia
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Abstract

Genomes evolve through a medley of mutation, drift, and selection, all of which act heterogeneously across genes and lineages. The pacemaker models of genomic evolution describe the resulting patterns of evolutionary rate variation: genes that are governed by the same pacemaker exhibit the same pattern of rate heterogeneity across lineages. However, the relative importance of drift and selection in determining the structure of these pacemakers is unknown. Here, we propose a novel phylogenetic approach to explain the formation of pacemakers. We apply this method to a genomic dataset from holometabolous insects, an ancient and diverse group of organisms. We show that when drift is the dominant evolutionary process, each pacemaker tends to govern a large number of fast-evolving genes. In contrast, strong negative selection leads to many distinct pacemakers, each of which governs a few slow-evolving genes. Our results provide new insights into the interplay between drift and selection in driving genomic evolution.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 31, 2016.
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The impacts of drift and selection on genomic evolution in holometabolous insects
K. Jun Tong, Sebastián Duchêne, Nathan Lo, Simon Y. W. Ho
bioRxiv 072512; doi: https://doi.org/10.1101/072512
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The impacts of drift and selection on genomic evolution in holometabolous insects
K. Jun Tong, Sebastián Duchêne, Nathan Lo, Simon Y. W. Ho
bioRxiv 072512; doi: https://doi.org/10.1101/072512

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