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Unraveling the differential dynamics of developmental fate in central and peripheral nervous systems

Dola Sengupta, Sandip Kar
doi: https://doi.org/10.1101/072579
Dola Sengupta
1Department of Chemistry, IIT Bombay, Powai, Mumbai - 400076, India
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Sandip Kar
1Department of Chemistry, IIT Bombay, Powai, Mumbai - 400076, India
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Abstract

Bone morphogenetic protein 2 (BMP2), differentially regulates the developmental lineage commitment of neural stem cells (NSC’s) in central and peripheral nervous systems. However, the precise mechanism beneath such observations still remains illusive. To decipher the intricacies of this mechanism, we propose a generic mathematical model of BMP2 driven differentiation regulation of NSC’s. The model efficiently captures the dynamics of the wild-type as well as various mutant and over-expression phenotypes for NSC’s in central nervous system. Our model predicts that the differential developmental dynamics of the NSC’s in peripheral nervous system can be reconciled by altering the relative positions of the two mutually interconnected bi-unstable switches inherently present in the steady state dynamics of the crucial developmental fate regulatory proteins as a function of BMP2 dose. This model thus provides a novel mechanistic insight and has the potential to deliver exciting therapeutic strategies for neuronal regeneration from NSC’s of different origin.

Footnotes

  • ↵* E-mail: sandipkar{at}iitb.ac.in

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted August 31, 2016.
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Unraveling the differential dynamics of developmental fate in central and peripheral nervous systems
Dola Sengupta, Sandip Kar
bioRxiv 072579; doi: https://doi.org/10.1101/072579
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Unraveling the differential dynamics of developmental fate in central and peripheral nervous systems
Dola Sengupta, Sandip Kar
bioRxiv 072579; doi: https://doi.org/10.1101/072579

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