New Results
CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer
View ORCID ProfileMalachi Griffith, View ORCID ProfileNicholas C Spies, View ORCID ProfileKilannin Krysiak, Adam C Coffman, Joshua F McMichael, Benjamin J Ainscough, Damian T Rieke, Arpad M Danos, Lynzey Kujan, Cody A Ramirez, Alex H Wagner, Zachary L Skidmore, Connor J Liu, Martin R Jones, Rachel L Bilski, Robert Lesurf, Erica K Barnell, Nakul M Shah, Melika Bonakdar, Lee Trani, Matthew Matlock, Avinash Ramu, Katie M Campbell, Gregory C Spies, Aaron P Graubert, Karthik Gangavarapu, James M Eldred, David E Larson, Jason R Walker, Benjamin M Good, Chunlei Wu, Andrew I Su, Rodrigo Dienstmann, Steven JM Jones, Ron Bose, David H Spencer, Lukas D Wartman, Richard K Wilson, Elaine R Mardis, View ORCID ProfileObi L Griffith
doi: https://doi.org/10.1101/072892
Malachi Griffith
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
2Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA
3Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
Nicholas C Spies
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Kilannin Krysiak
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Adam C Coffman
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Joshua F McMichael
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Benjamin J Ainscough
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
2Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA
3Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
Damian T Rieke
4Charité Comprehensive Cancer Center, Charité – Universitätsmedizin Berlin, Berlin, Germany
Arpad M Danos
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Lynzey Kujan
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Cody A Ramirez
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Alex H Wagner
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
2Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA
Zachary L Skidmore
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Connor J Liu
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Martin R Jones
5Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada
Rachel L Bilski
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Robert Lesurf
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Erica K Barnell
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Nakul M Shah
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Melika Bonakdar
5Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada
Lee Trani
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Matthew Matlock
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Avinash Ramu
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Katie M Campbell
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Gregory C Spies
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Aaron P Graubert
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Karthik Gangavarapu
6Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
James M Eldred
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
David E Larson
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
3Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
Jason R Walker
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
Benjamin M Good
6Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
Chunlei Wu
6Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
Andrew I Su
6Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
Rodrigo Dienstmann
7Oncology Data Science Group, Vall d’Hebron Institute of Oncology, Barcelona, Spain
Steven JM Jones
5Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada
Ron Bose
8Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
David H Spencer
8Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Lukas D Wartman
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
2Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA
8Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Richard K Wilson
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
2Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA
3Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
8Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Elaine R Mardis
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
2Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA
3Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
8Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
Obi L Griffith
1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA
2Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA
3Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
8Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA

Abstract
CIViC is an expert crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer (www.civicdb.org) describing the therapeutic, prognostic, and diagnostic relevance of inherited and somatic variants of all types. CIViC is committed to open source code, open access content, public application programming interfaces (APIs), and provenance of supporting evidence to allow for the transparent creation of current and accurate variant interpretations for use in cancer precision medicine.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Posted September 01, 2016.
CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer
Malachi Griffith, Nicholas C Spies, Kilannin Krysiak, Adam C Coffman, Joshua F McMichael, Benjamin J Ainscough, Damian T Rieke, Arpad M Danos, Lynzey Kujan, Cody A Ramirez, Alex H Wagner, Zachary L Skidmore, Connor J Liu, Martin R Jones, Rachel L Bilski, Robert Lesurf, Erica K Barnell, Nakul M Shah, Melika Bonakdar, Lee Trani, Matthew Matlock, Avinash Ramu, Katie M Campbell, Gregory C Spies, Aaron P Graubert, Karthik Gangavarapu, James M Eldred, David E Larson, Jason R Walker, Benjamin M Good, Chunlei Wu, Andrew I Su, Rodrigo Dienstmann, Steven JM Jones, Ron Bose, David H Spencer, Lukas D Wartman, Richard K Wilson, Elaine R Mardis, Obi L Griffith
bioRxiv 072892; doi: https://doi.org/10.1101/072892
CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer
Malachi Griffith, Nicholas C Spies, Kilannin Krysiak, Adam C Coffman, Joshua F McMichael, Benjamin J Ainscough, Damian T Rieke, Arpad M Danos, Lynzey Kujan, Cody A Ramirez, Alex H Wagner, Zachary L Skidmore, Connor J Liu, Martin R Jones, Rachel L Bilski, Robert Lesurf, Erica K Barnell, Nakul M Shah, Melika Bonakdar, Lee Trani, Matthew Matlock, Avinash Ramu, Katie M Campbell, Gregory C Spies, Aaron P Graubert, Karthik Gangavarapu, James M Eldred, David E Larson, Jason R Walker, Benjamin M Good, Chunlei Wu, Andrew I Su, Rodrigo Dienstmann, Steven JM Jones, Ron Bose, David H Spencer, Lukas D Wartman, Richard K Wilson, Elaine R Mardis, Obi L Griffith
bioRxiv 072892; doi: https://doi.org/10.1101/072892
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