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Prefrontal cortical control of a brainstem social behavior circuit

Tamara B. Franklin, Bianca A. Silva, Zina Perova, Livia Marrone, Maria E. Masferrer, Yang Zhan, Angie Kaplan, Louise Greetham, Violaine Verrechia, Andreas Halman, Sara Pagella, Alexei L. Vyssotski, Anna Illarionova, Valery Grinevich, Tiago Branco, Cornelius T. Gross
doi: https://doi.org/10.1101/073734
Tamara B. Franklin
1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, 00015 Monterotondo, Italy.
2Department of Psychology and Neuroscience, Dalhousie University, 1355 Oxford Street, Halifax, Canada B3H 4R2.
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Bianca A. Silva
1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, 00015 Monterotondo, Italy.
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Zina Perova
3MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
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Livia Marrone
1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, 00015 Monterotondo, Italy.
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Maria E. Masferrer
1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, 00015 Monterotondo, Italy.
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Yang Zhan
1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, 00015 Monterotondo, Italy.
4Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 518055.
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Angie Kaplan
1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, 00015 Monterotondo, Italy.
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Louise Greetham
1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, 00015 Monterotondo, Italy.
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Violaine Verrechia
1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, 00015 Monterotondo, Italy.
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Andreas Halman
1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, 00015 Monterotondo, Italy.
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Sara Pagella
1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, 00015 Monterotondo, Italy.
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Alexei L. Vyssotski
5Institute of Neuroinformatics, University of Zürich and Swiss Federal Institute of Technology (ETH), Winterthurerstr. 190, 8057 Zurich, Switzerland.
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Anna Illarionova
6Schaller Research Group on Neuropeptides, German Cancer Research Center DKFZ, Cell Network Cluster of Excellence, University of Heidelberg, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
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Valery Grinevich
6Schaller Research Group on Neuropeptides, German Cancer Research Center DKFZ, Cell Network Cluster of Excellence, University of Heidelberg, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
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Tiago Branco
3MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
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Cornelius T. Gross
1Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), via Ramarini 32, 00015 Monterotondo, Italy.
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  • For correspondence: gross@embl.it
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Summary

The prefrontal cortex plays a critical role in adjusting an organism’s behavior to its environment. In particular, numerous studies have implicated the prefrontal cortex in the control of social behavior, but the neural circuits that mediate these effects remain unknown. Here we investigated behavioral adaptation to social defeat in mice and uncovered a critical contribution of neural projections from the medial prefrontal cortex to the dorsal periaqueductal grey, a brainstem area vital for defensive responses. Social defeat caused a weakening of functional connectivity between these two areas and selective inhibition of these projections mimicked the behavioral effects of social defeat. These findings define a specific neural projection by which the prefrontal cortex can control and adapt social behavior.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 09, 2016.
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Prefrontal cortical control of a brainstem social behavior circuit
Tamara B. Franklin, Bianca A. Silva, Zina Perova, Livia Marrone, Maria E. Masferrer, Yang Zhan, Angie Kaplan, Louise Greetham, Violaine Verrechia, Andreas Halman, Sara Pagella, Alexei L. Vyssotski, Anna Illarionova, Valery Grinevich, Tiago Branco, Cornelius T. Gross
bioRxiv 073734; doi: https://doi.org/10.1101/073734
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Prefrontal cortical control of a brainstem social behavior circuit
Tamara B. Franklin, Bianca A. Silva, Zina Perova, Livia Marrone, Maria E. Masferrer, Yang Zhan, Angie Kaplan, Louise Greetham, Violaine Verrechia, Andreas Halman, Sara Pagella, Alexei L. Vyssotski, Anna Illarionova, Valery Grinevich, Tiago Branco, Cornelius T. Gross
bioRxiv 073734; doi: https://doi.org/10.1101/073734

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