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Na-Dene populations descend from the Paleo-Eskimo migration into America

Pavel Flegontov, N. Ezgi Altınışık, Piya Changmai, Edward J. Vajda, Johannes Krause, Stephan Schiffels
doi: https://doi.org/10.1101/074476
Pavel Flegontov
1Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic
2A.A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia
3Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budĕjovice, Czech Republic
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  • For correspondence: schiffels@shh.mpg.de pavel.flegontov@osu.cz
N. Ezgi Altınışık
1Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic
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Piya Changmai
1Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic
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Edward J. Vajda
4Department of Modern and Classical Languages, Western Washington University, Bellingham, WA, USA
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Johannes Krause
5Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Kahlaische Str. 10, 07745 Jena, Germany
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Stephan Schiffels
5Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Kahlaische Str. 10, 07745 Jena, Germany
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  • For correspondence: schiffels@shh.mpg.de pavel.flegontov@osu.cz
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Abstract

Prehistory of Native Americans of the Na-Dene language family remains controversial. Genetic continuity of Paleo-Eskimos (Saqqaq and Dorset cultures) and Na-Dene was proposed under the three-wave model of America’s settlement; however, recent studies have produced conflicting results. Here, we performed reconstruction and dating of Na-Dene population history, using genome sequencing data and a coalescent method relying on rare alleles (Rarecoal). We also applied model-free approaches for analysis of rare allele and autosomal haplotype sharing. All methods detected Central and West Siberian ancestry exclusively in a fraction of modern day Na-Dene individuals, but not in other Native Americans. Our results are consistent with gene flow from Paleo-Eskimos into the First American ancestors of Na-Dene, and a later less extensive bidirectional admixture between Na-Dene and Neo-Eskimos. The dated gene flow from Siberia to Na-Dene is in agreement with the Dene-Yeniseian language macrofamily proposal and with the succession of archaeological cultures in Siberia.

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Posted September 13, 2016.
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Na-Dene populations descend from the Paleo-Eskimo migration into America
Pavel Flegontov, N. Ezgi Altınışık, Piya Changmai, Edward J. Vajda, Johannes Krause, Stephan Schiffels
bioRxiv 074476; doi: https://doi.org/10.1101/074476
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Na-Dene populations descend from the Paleo-Eskimo migration into America
Pavel Flegontov, N. Ezgi Altınışık, Piya Changmai, Edward J. Vajda, Johannes Krause, Stephan Schiffels
bioRxiv 074476; doi: https://doi.org/10.1101/074476

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