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Optokinetic nystagmus reflects perceptual directions in the onset binocular rivalry in Parkinson’s disease

Mana Fujiwara, Catherine Ding, Lisandro Kaunitz, Julie C Stout, Dominic Thyagarajan, Naotsugu Tsuchiya
doi: https://doi.org/10.1101/074898
Mana Fujiwara
1School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia
2Araya Brain Imaging, Tokyo, Japan
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Catherine Ding
3Department of Neurosciences, Southern Clinical School, Monash Health, Melbourne, Victoria, Australia
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Lisandro Kaunitz
1School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia
4Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo, Japan
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Julie C Stout
1School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia
5Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Victoria, Australia
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Dominic Thyagarajan
3Department of Neurosciences, Southern Clinical School, Monash Health, Melbourne, Victoria, Australia
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  • For correspondence: naotsugu.tsuchiya@monash.edu dominic.thyagarajan@monash.edu
Naotsugu Tsuchiya
1School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia
5Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Victoria, Australia
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  • For correspondence: naotsugu.tsuchiya@monash.edu dominic.thyagarajan@monash.edu
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Abstract

Optokinetic nystagmus (OKN), the reflexive eye movements evoked by a moving field, has recently gained interest among researchers as a useful tool to assess conscious perception. When conscious perception and stimulus are dissociated, such as in binocular rivalry —when dissimilar images are simultaneously presented to each eye and perception alternates between the two images over time — OKN correlates with perception rather than with the physical direction of the moving field. While this relationship is well established in healthy subjects it is yet unclear whether it also generalizes to clinical populations, for example, patients with Parkinson’s disease. Parkinson’s disease is a motor disorder, causing tremor, slow movements and rigidity. It may also be associated with oculomotor deficits, such as impaired saccades and smooth pursuit eye movements. Here, we employed short-duration, onset binocular rivalry (2 s trial of stimulus presentation followed by 1 s inter-trial interval) with moving grating stimuli to assess OKN in Parkinson’s disease patients (N=39) and controls (N=29) of a similar age. Each trial was either non-rivalrous (same stimuli presented to both eyes) or rivalrous, as in binocular rivalry. We analyzed OKN to discriminate direction of stimulus and perception on a trial-by-trial basis. OKN reflected conscious perceptions in both groups. Treatment with anti-Parkinson drugs and deep brain stimulation improved motor ability of patients assessed by a standard scale of Parkinson’s disease, but did not impact on OKN. Furthermore, OKN-based measures were robust and their latencies were shorter than manual button-based measures in all subjects, regardless of stimulus condition. Our findings suggest that OKN can be used as an indicator of conscious perception in binocular rivalry even in Parkinson’s disease patients in whom impaired manual dexterity may render button-press reports less reliable.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted September 13, 2016.
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Optokinetic nystagmus reflects perceptual directions in the onset binocular rivalry in Parkinson’s disease
Mana Fujiwara, Catherine Ding, Lisandro Kaunitz, Julie C Stout, Dominic Thyagarajan, Naotsugu Tsuchiya
bioRxiv 074898; doi: https://doi.org/10.1101/074898
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Optokinetic nystagmus reflects perceptual directions in the onset binocular rivalry in Parkinson’s disease
Mana Fujiwara, Catherine Ding, Lisandro Kaunitz, Julie C Stout, Dominic Thyagarajan, Naotsugu Tsuchiya
bioRxiv 074898; doi: https://doi.org/10.1101/074898

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