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State-dependent modulation of functional connectivity in early blind individuals

Maxime Pelland, Pierre Orban, View ORCID ProfileChristian Dansereau, Franco Lepore, View ORCID ProfilePierre Bellec, Olivier Collignon
doi: https://doi.org/10.1101/075465
Maxime Pelland
1Departement of Psychology, University of Montreal, Montreal, Quebec, Canada
2Centre de Recherche en Neuropsychologie et Cognition, University of Montreal, Montreal, QC, Canada
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Pierre Orban
3Functional Neuroimaging Unit, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, University of Montreal, Montreal, Quebec, Canada
4Department of Psychiatry, University of Montreal, Montreal, Quebec, Canada
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Christian Dansereau
3Functional Neuroimaging Unit, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, University of Montreal, Montreal, Quebec, Canada
5Department of Computer Science and Operations Research, University of Montreal, Montreal, Quebec, Canada
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Franco Lepore
1Departement of Psychology, University of Montreal, Montreal, Quebec, Canada
2Centre de Recherche en Neuropsychologie et Cognition, University of Montreal, Montreal, QC, Canada
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Pierre Bellec
3Functional Neuroimaging Unit, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, University of Montreal, Montreal, Quebec, Canada
5Department of Computer Science and Operations Research, University of Montreal, Montreal, Quebec, Canada
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Olivier Collignon
6Institute of Psychology (IPSY) and Institute of Neuroscience (IoNS), Université catholique de Louvain, Belgium.
7Center for Mind/Brain Science (CIMeC), Università di Trento.
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Abstract

Resting-state functional connectivity (RSFC) studies have highlighted how visual experience influences the brain’s functional architecture. Reduced RSFC coupling between occipital (visual) and temporal (auditory) regions has been reliably observed in early blind individuals (EB) at rest. In contrast, task-dependent activation studies have repeatedly demonstrated enhanced co-activation and connectivity of occipital and temporal regions during auditory processing in EB. To investigate this apparent discrepancy, the functional coupling between temporal and occipital networks at rest was directly compared to that of an auditory task in both EB and sighted controls (SC). Functional brain clusters shared across groups and cognitive states (rest and auditory task) were defined. In EBs, we observed higher occipito-temporal correlations in activity during the task than at rest. The reverse pattern was observed in SC. We also observed higher temporal variability of occipito-temporal RSFC in EB suggesting that occipital regions in this population may play a role of multiple demand system. Our study reveals how the connectivity profile of sighted and early blind people is differentially influenced by their cognitive state, bridging the gap between previous task-dependent and RSFC studies. Our results also highlight how inferring group-differences in functional brain architecture solely based on resting-state acquisition has to be considered with caution.

Highlights

  1. Occipito-temporal functional connectivity is modified by cognitive states.

  2. This modulation is different in blind and sighted individuals.

  3. Blind participants have higher occipito-temporal temporal variability at rest.

  4. The group difference in variability at rest explains the differences in modulation.

  5. Inferring group differences with resting-state data should be subject to caution.

Footnotes

  • Olivier Collignon, CIMeC – Center for Mind/Brain Sciences, University of Trento, via delle Regole 101, Mattarello (TN), Italy; Phone: +39 0461 282778, Fax: +39 0461 883066.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted September 16, 2016.
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State-dependent modulation of functional connectivity in early blind individuals
Maxime Pelland, Pierre Orban, Christian Dansereau, Franco Lepore, Pierre Bellec, Olivier Collignon
bioRxiv 075465; doi: https://doi.org/10.1101/075465
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State-dependent modulation of functional connectivity in early blind individuals
Maxime Pelland, Pierre Orban, Christian Dansereau, Franco Lepore, Pierre Bellec, Olivier Collignon
bioRxiv 075465; doi: https://doi.org/10.1101/075465

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