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Estimating the Selective Effect of Heterozygous Protein Truncating Variants from Human Exome Data

View ORCID ProfileChristopher A. Cassa, Donate Weghorn, Daniel J. Balick, Daniel M. Jordan, David Nusinow, Kaitlin E. Samocha, Anne O'Donnell Luria, Daniel G. MacArthur, Mark J. Daly, David R. Beier, Shamil R. Sunyaev
doi: https://doi.org/10.1101/075523
Christopher A. Cassa
1Brigham and Women’s Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
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  • ORCID record for Christopher A. Cassa
Donate Weghorn
1Brigham and Women’s Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USA
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Daniel J. Balick
1Brigham and Women’s Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USA
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Daniel M. Jordan
3Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
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David Nusinow
1Brigham and Women’s Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USA
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Kaitlin E. Samocha
4Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
5Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA
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Anne O'Donnell Luria
4Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
6Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA, USA
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Daniel G. MacArthur
2Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
4Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
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Mark J. Daly
2Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
4Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
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David R. Beier
7Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, Seattle, WA, USA
8Dept. of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA
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  • For correspondence: ssunyaev@rics.bwh.harvard.edu David.Beier@seattlechildrens.org
Shamil R. Sunyaev
1Brigham and Women’s Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
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  • For correspondence: ssunyaev@rics.bwh.harvard.edu David.Beier@seattlechildrens.org
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Posted September 16, 2016.
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Estimating the Selective Effect of Heterozygous Protein Truncating Variants from Human Exome Data
Christopher A. Cassa, Donate Weghorn, Daniel J. Balick, Daniel M. Jordan, David Nusinow, Kaitlin E. Samocha, Anne O'Donnell Luria, Daniel G. MacArthur, Mark J. Daly, David R. Beier, Shamil R. Sunyaev
bioRxiv 075523; doi: https://doi.org/10.1101/075523
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Estimating the Selective Effect of Heterozygous Protein Truncating Variants from Human Exome Data
Christopher A. Cassa, Donate Weghorn, Daniel J. Balick, Daniel M. Jordan, David Nusinow, Kaitlin E. Samocha, Anne O'Donnell Luria, Daniel G. MacArthur, Mark J. Daly, David R. Beier, Shamil R. Sunyaev
bioRxiv 075523; doi: https://doi.org/10.1101/075523

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