Estimating the Selective Effect of Heterozygous Protein Truncating Variants from Human Exome Data

Christopher A. Cassa; Donate Weghorn; Daniel J. Balick; Daniel M. Jordan; David Nusinow; Kaitlin E. Samocha; Anne O'Donnell Luria; Daniel G. MacArthur; Mark J. Daly; David R. Beier; Shamil R. Sunyaev

doi:10.1101/075523

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Estimating the Selective Effect of Heterozygous Protein Truncating Variants from Human Exome Data

View ORCID ProfileChristopher A. Cassa, Donate Weghorn, Daniel J. Balick, Daniel M. Jordan, David Nusinow, Kaitlin E. Samocha, Anne O'Donnell Luria, Daniel G. MacArthur, Mark J. Daly, David R. Beier, Shamil R. Sunyaev

doi: https://doi.org/10.1101/075523

Christopher A. Cassa

Brigham and Women’s Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USAProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

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ORCID record for Christopher A. Cassa

Donate Weghorn

Brigham and Women’s Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USA

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Daniel J. Balick

Brigham and Women’s Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USA

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Daniel M. Jordan

Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

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David Nusinow

Brigham and Women’s Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USA

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Kaitlin E. Samocha

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAProgram in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA

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Anne O'Donnell Luria

Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USADivision of Genetics and Genomics, Boston Children’s Hospital, Boston, MA, USA

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Daniel G. MacArthur

Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

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Mark J. Daly

Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USAAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

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David R. Beier

Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, Seattle, WA, USADept. of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA

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For correspondence: ssunyaev@rics.bwh.harvard.edu David.Beier@seattlechildrens.org

Shamil R. Sunyaev

Brigham and Women’s Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USAProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

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For correspondence: ssunyaev@rics.bwh.harvard.edu David.Beier@seattlechildrens.org

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Posted September 16, 2016.

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Estimating the Selective Effect of Heterozygous Protein Truncating Variants from Human Exome Data

Christopher A. Cassa, Donate Weghorn, Daniel J. Balick, Daniel M. Jordan, David Nusinow, Kaitlin E. Samocha, Anne O'Donnell Luria, Daniel G. MacArthur, Mark J. Daly, David R. Beier, Shamil R. Sunyaev

bioRxiv 075523; doi: https://doi.org/10.1101/075523

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Estimating the Selective Effect of Heterozygous Protein Truncating Variants from Human Exome Data

Christopher A. Cassa, Donate Weghorn, Daniel J. Balick, Daniel M. Jordan, David Nusinow, Kaitlin E. Samocha, Anne O'Donnell Luria, Daniel G. MacArthur, Mark J. Daly, David R. Beier, Shamil R. Sunyaev

bioRxiv 075523; doi: https://doi.org/10.1101/075523

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