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Optimal use of EEG recordings to target active brain areas with transcranial electrical stimulation

Jacek P. Dmochowski, Laurent Koessler, Anthony M. Norcia, Marom Bikson, Lucas C. Parra
doi: https://doi.org/10.1101/078758
Jacek P. Dmochowski
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Laurent Koessler
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Anthony M. Norcia
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Marom Bikson
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Lucas C. Parra
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Abstract

To demonstrate causal relationships between brain and behavior, investigators would like to guide brain stimulation using measurements of neural activity. Particularly promising in this context are electroen-cephalography (EEG) and transcranial electrical stimulation (TES), as they are linked by a reciprocity principle which, despite being known for decades, has not led to a formalism for relating EEG recordings to optimal stimulation parameters. Here we derive a closed-form expression for the TES configuration that optimally stimulates (i.e., targets) the sources of recorded EEG, without making any assumptions about source location or distribution. We also derive a duality between TES targeting and EEG source localization, and demonstrate that in cases where source localization fails, so does the proposed targeting. Numerical simulations with realistic head models confirm these theoretical predictions and quantify the achieved stimulation in terms of focality and intensity. We show that constraining the stimulation currents can lead to optimal montages that involve only a few electrodes, with only a minor loss in performance. The proposed technique allows brain scientists and clinicians to rationally target the sources of observed EEG and thus overcomes a major obstacle to the realization of closed-loop brain stimulation.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 19, 2016.
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Optimal use of EEG recordings to target active brain areas with transcranial electrical stimulation
Jacek P. Dmochowski, Laurent Koessler, Anthony M. Norcia, Marom Bikson, Lucas C. Parra
bioRxiv 078758; doi: https://doi.org/10.1101/078758
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Optimal use of EEG recordings to target active brain areas with transcranial electrical stimulation
Jacek P. Dmochowski, Laurent Koessler, Anthony M. Norcia, Marom Bikson, Lucas C. Parra
bioRxiv 078758; doi: https://doi.org/10.1101/078758

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