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Reproducibility and replicability of rodent phenotyping in preclinical studies

Neri Kafkafi, Joseph Agassi, Elissa J. Chesler, John C. Crabbe, Wim E. Crusio, David Eilam, Robert Gerlai, Ilan Golani, Alex Gomez-Marin, Ruth Heller, Fuad Iraqi, Iman Jaljuli, Natasha A. Karp, Hugh Morgan, George Nicholson, Donald W. Pfaff, S. Helene Richter, Philip B. Stark, Oliver Stiedl, Victoria Stodden, Lisa M. Tarantino, Valter Tucci, William Valdar, Robert W. Williams, Hanno Würbel, Yoav Benjamini
doi: https://doi.org/10.1101/079350
Neri Kafkafi
1Tel Aviv University
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Joseph Agassi
1Tel Aviv University
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Elissa J. Chesler
2The Jackson Laboratory
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John C. Crabbe
3Oregon Health & Science University
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Wim E. Crusio
4INCIA Université de Bordeaux and CNRS
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David Eilam
1Tel Aviv University
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Robert Gerlai
5University of Toronto
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Ilan Golani
1Tel Aviv University
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Alex Gomez-Marin
6Instituto de Neurociencias CSIC-UMH, Alicante, Spain
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Ruth Heller
1Tel Aviv University
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Fuad Iraqi
1Tel Aviv University
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Iman Jaljuli
1Tel Aviv University
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Natasha A. Karp
7Wellcome Trust Sanger Institute
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Hugh Morgan
8Harwell Research Center
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George Nicholson
9Oxford University
16Istituto Italiano di Tecnologia
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Donald W. Pfaff
10Rockefeller University
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S. Helene Richter
11University of Muenster
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Philip B. Stark
12University of California Berkeley
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Oliver Stiedl
13VU University Amsterdam
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Victoria Stodden
14University of Illinois at Urbana-Champaign
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Lisa M. Tarantino
15University of North Carolina at Chapel Hill
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Valter Tucci
16Istituto Italiano di Tecnologia
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William Valdar
17University of North Carolina at Chapel Hill
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Robert W. Williams
18University of Tennessee Health Science Center
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Hanno Würbel
19University of Bern.
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Yoav Benjamini
1Tel Aviv University
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Abstract

The scientific community is increasingly concerned with cases of published “discoveries” that are not replicated in further studies. The field of mouse behavioral phenotyping was one of the first to raise this concern, and to relate it to other complicated methodological issues: the complex interaction between genotype and environment; the definitions of behavioral constructs; and the use of the mouse as a model animal for human health and disease mechanisms. In January 2015, researchers from various disciplines including genetics, behavior genetics, neuroscience, ethology, statistics and bioinformatics gathered in Tel Aviv University to discuss these issues. The general consent presented here was that the issue is prevalent and of concern, and should be addressed at the statistical, methodological and policy levels, but is not so severe as to call into question the validity and the usefulness of model organisms as a whole. Well-organized community efforts, coupled with improved data and metadata sharing, were agreed by all to have a key role to play in identifying specific problems and promoting effective solutions. As replicability is related to validity and may also affect generalizability and translation of findings, the implications of the present discussion reach far beyond the issue of replicability of mouse phenotypes but may be highly relevant throughout biomedical research.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted October 17, 2016.
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Reproducibility and replicability of rodent phenotyping in preclinical studies
Neri Kafkafi, Joseph Agassi, Elissa J. Chesler, John C. Crabbe, Wim E. Crusio, David Eilam, Robert Gerlai, Ilan Golani, Alex Gomez-Marin, Ruth Heller, Fuad Iraqi, Iman Jaljuli, Natasha A. Karp, Hugh Morgan, George Nicholson, Donald W. Pfaff, S. Helene Richter, Philip B. Stark, Oliver Stiedl, Victoria Stodden, Lisa M. Tarantino, Valter Tucci, William Valdar, Robert W. Williams, Hanno Würbel, Yoav Benjamini
bioRxiv 079350; doi: https://doi.org/10.1101/079350
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Reproducibility and replicability of rodent phenotyping in preclinical studies
Neri Kafkafi, Joseph Agassi, Elissa J. Chesler, John C. Crabbe, Wim E. Crusio, David Eilam, Robert Gerlai, Ilan Golani, Alex Gomez-Marin, Ruth Heller, Fuad Iraqi, Iman Jaljuli, Natasha A. Karp, Hugh Morgan, George Nicholson, Donald W. Pfaff, S. Helene Richter, Philip B. Stark, Oliver Stiedl, Victoria Stodden, Lisa M. Tarantino, Valter Tucci, William Valdar, Robert W. Williams, Hanno Würbel, Yoav Benjamini
bioRxiv 079350; doi: https://doi.org/10.1101/079350

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