Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Multiplexed computations in retinal ganglion cells of a single type

View ORCID ProfileStephane Deny, View ORCID ProfileUlisse Ferrari, View ORCID ProfileEmilie Mace, Pierre Yger, Romain Caplette, Serge Picaud, View ORCID ProfileGašper Tkačik, View ORCID ProfileOlivier Marre
doi: https://doi.org/10.1101/080135
Stephane Deny
1Institut de la Vision, INSERM UMRS 968, UPMC UM 80, CNRS UMR 7210, Paris
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Stephane Deny
Ulisse Ferrari
1Institut de la Vision, INSERM UMRS 968, UPMC UM 80, CNRS UMR 7210, Paris
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ulisse Ferrari
Emilie Mace
1Institut de la Vision, INSERM UMRS 968, UPMC UM 80, CNRS UMR 7210, Paris
2Present address: Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Maulbeer-strasse 66, 4058 Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Emilie Mace
Pierre Yger
1Institut de la Vision, INSERM UMRS 968, UPMC UM 80, CNRS UMR 7210, Paris
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Romain Caplette
1Institut de la Vision, INSERM UMRS 968, UPMC UM 80, CNRS UMR 7210, Paris
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Serge Picaud
1Institut de la Vision, INSERM UMRS 968, UPMC UM 80, CNRS UMR 7210, Paris
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gašper Tkačik
3Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gašper Tkačik
Olivier Marre
1Institut de la Vision, INSERM UMRS 968, UPMC UM 80, CNRS UMR 7210, Paris
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Olivier Marre
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

In the early visual system, cells of the same type perform the same computation in di↵erent places of the visual field. How these cells code together a complex visual scene is unclear. A common assumption is that cells of the same type will extract a single stimulus feature to form a feature map, but this has rarely been observed directly. Using large-scale recordings in the rat retina, we show that a homogeneous population of fast OFF ganglion cells simultaneously encodes two radically different features of a visual scene. Cells close to a moving object code linearly for its position, while distant cells remain largely invariant to the object’s position and, instead, respond non-linearly to changes in the object’s speed. Cells switch between these two computations depending on the stimulus. We developed a quantitative model that accounts for this effect and identified a likely disinhibitory circuit that mediates it. Ganglion cells of a single type thus do not code for one, but two features simultaneously. This richer, flexible neural map might also be present in other sensory systems.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Back to top
PreviousNext
Posted October 10, 2016.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Multiplexed computations in retinal ganglion cells of a single type
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Multiplexed computations in retinal ganglion cells of a single type
Stephane Deny, Ulisse Ferrari, Emilie Mace, Pierre Yger, Romain Caplette, Serge Picaud, Gašper Tkačik, Olivier Marre
bioRxiv 080135; doi: https://doi.org/10.1101/080135
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Multiplexed computations in retinal ganglion cells of a single type
Stephane Deny, Ulisse Ferrari, Emilie Mace, Pierre Yger, Romain Caplette, Serge Picaud, Gašper Tkačik, Olivier Marre
bioRxiv 080135; doi: https://doi.org/10.1101/080135

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Subject Areas
All Articles
  • Animal Behavior and Cognition (4380)
  • Biochemistry (9571)
  • Bioengineering (7084)
  • Bioinformatics (24832)
  • Biophysics (12595)
  • Cancer Biology (9949)
  • Cell Biology (14344)
  • Clinical Trials (138)
  • Developmental Biology (7943)
  • Ecology (12095)
  • Epidemiology (2067)
  • Evolutionary Biology (15980)
  • Genetics (10915)
  • Genomics (14730)
  • Immunology (9862)
  • Microbiology (23636)
  • Molecular Biology (9472)
  • Neuroscience (50824)
  • Paleontology (369)
  • Pathology (1538)
  • Pharmacology and Toxicology (2678)
  • Physiology (4009)
  • Plant Biology (8653)
  • Scientific Communication and Education (1508)
  • Synthetic Biology (2389)
  • Systems Biology (6422)
  • Zoology (1345)