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Lysine as a potential low molecular weight angiogen: its clinical, experimental and in-silico validation- A brief study

Debatosh Datta, Priyanshu Verma, Anindita Banerjee, Sujoy Kar, Tanima Sengupta, Nalinava Sengupta, Sujoy Kumar Samanta, Enam Murshed Khan
doi: https://doi.org/10.1101/080176
Debatosh Datta
1Department of Chemical and Biochemical Engineering, IIT Patna, India
3Apollo-Gleneagles Hospital, Kolkata, India
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  • For correspondence: debatoshdtt@gmail.com
Priyanshu Verma
1Department of Chemical and Biochemical Engineering, IIT Patna, India
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Anindita Banerjee
2Department of Biochemistry, ICARE Institute of Medical Sciences and Research, Haldia, India
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Sujoy Kar
3Apollo-Gleneagles Hospital, Kolkata, India
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Tanima Sengupta
4Epigen, Akershus Universitetssykehus, 1478 Lorenskog, Norway
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Nalinava Sengupta
5iNANOD AS, Oslo, Norway
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Sujoy Kumar Samanta
1Department of Chemical and Biochemical Engineering, IIT Patna, India
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Enam Murshed Khan
3Apollo-Gleneagles Hospital, Kolkata, India
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Abstract

Globally, the area of angiogenesis is dominated by investigations on anti-angiogenic agents and processes, due to its role in metastatic cancer treatment. Although, the area of ischemic tissue reperfusion is having much bigger demand and foot-mark. Following clinical failure of VEGF (Vascular endothelial growth factor) as a potential agent for induction of a controlled angiogenic response in ischemic tissues and organs, the progress is reasonably quiet as for new low molecular weight (LMW) angiogen molecules and their clinical applications are concerned. Basic amino acid Lysine has been observed to have profound angiogenic property in ischemic tissues, which is controlled, reproducible, time bound and without any accompanying reperfusion damage. In this study, the basic amino acid Lysine has been suggested as a LMW-angiogen, where it has been proposed to have a molecular binding property between VEGF and VEGF receptor (VEGFR). Here, the molecular adhesive hypothesis is being probed and confirmed both in the clinical and lab conditions through induced angiogenic response in tissue repair and in chick chorio allantoic membrane (CAM), respectively; and in dry-docking experiments (in-silico studies).

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Posted October 12, 2016.
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Lysine as a potential low molecular weight angiogen: its clinical, experimental and in-silico validation- A brief study
Debatosh Datta, Priyanshu Verma, Anindita Banerjee, Sujoy Kar, Tanima Sengupta, Nalinava Sengupta, Sujoy Kumar Samanta, Enam Murshed Khan
bioRxiv 080176; doi: https://doi.org/10.1101/080176
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Lysine as a potential low molecular weight angiogen: its clinical, experimental and in-silico validation- A brief study
Debatosh Datta, Priyanshu Verma, Anindita Banerjee, Sujoy Kar, Tanima Sengupta, Nalinava Sengupta, Sujoy Kumar Samanta, Enam Murshed Khan
bioRxiv 080176; doi: https://doi.org/10.1101/080176

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