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Ribbon: Visualizing complex genome alignments and structural variation

View ORCID ProfileMaria Nattestad, Chen-Shan Chin, View ORCID ProfileMichael C. Schatz
doi: https://doi.org/10.1101/082123
Maria Nattestad
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
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Chen-Shan Chin
2Pacific Biosciences, Menlo Park, California, USA.
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Michael C. Schatz
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
3Departments of Computer Science and Biology, Johns Hopkins University, Baltimore, MD, USA. e-mail:
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  • For correspondence: mnattest@cshl.edu
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Abstract

To the Editor Visualization has played an extremely important role in the current genomic revolution to inspect and understand variants, expression patterns, evolutionary changes, and a number of other relationships1–3. However, most of the information in read-to-reference or genome-genome alignments is lost for structural variations in the one-dimensional views of most genome browsers showing only reference coordinates. Instead, structural variations captured by long reads or assembled contigs often need more context to understand, including alignments and other genomic information from multiple chromosomes.

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Posted October 20, 2016.
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Ribbon: Visualizing complex genome alignments and structural variation
Maria Nattestad, Chen-Shan Chin, Michael C. Schatz
bioRxiv 082123; doi: https://doi.org/10.1101/082123
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Ribbon: Visualizing complex genome alignments and structural variation
Maria Nattestad, Chen-Shan Chin, Michael C. Schatz
bioRxiv 082123; doi: https://doi.org/10.1101/082123

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