Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Lineage structure of Streptococcus pneumoniae is driven by immune selection on the groEL heat-shock protein

View ORCID ProfileJosé Lourenço, Eleanor R. Watkins, Uri Obolski, Samuel J. Peacock, Callum Morris, Martin C. J. Maiden, Sunetra Gupta
doi: https://doi.org/10.1101/082990
José Lourenço
1Department of Zoology, University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for José Lourenço
Eleanor R. Watkins
1Department of Zoology, University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Uri Obolski
1Department of Zoology, University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Samuel J. Peacock
1Department of Zoology, University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Callum Morris
2University of Durham, Durham, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin C. J. Maiden
1Department of Zoology, University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sunetra Gupta
1Department of Zoology, University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

ABSTRACT

Populations of Streptococcus pneumoniae (SP) are typically structured into groups of closely related organisms or lineages, but it is not clear whether they are maintained by selection or neutral processes. Here, we attempt to address this question by applying a machine learning technique to SP whole genomes. Our results indicate that lineages evolved through immune selection on the groEL chaperone protein. The groEL protein is part of the groESL operon and enables a large range of proteins to fold correctly within the physical environment of the nasopharynx, thereby explaining why lineage structure is so stable within SP despite high levels of genetic transfer. SP is also antigenically diverse, exhibiting a variety of distinct capsular serotypes. Associations exist between lineage and capsular serotype but these can be easily perturbed, such as by vaccination. Overall, our analyses indicate that the evolution of SP can be conceptualized as the rearrangement of modular functional units occurring on several different timescales under different pressures: some patterns have locked in early (such as the epistatic interactions between groESL and a constellation of other genes) and preserve the differentiation of lineages, while others (such as the associations between capsular serotype and lineage) remain in continuous flux.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted July 05, 2017.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Lineage structure of Streptococcus pneumoniae is driven by immune selection on the groEL heat-shock protein
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Lineage structure of Streptococcus pneumoniae is driven by immune selection on the groEL heat-shock protein
José Lourenço, Eleanor R. Watkins, Uri Obolski, Samuel J. Peacock, Callum Morris, Martin C. J. Maiden, Sunetra Gupta
bioRxiv 082990; doi: https://doi.org/10.1101/082990
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Lineage structure of Streptococcus pneumoniae is driven by immune selection on the groEL heat-shock protein
José Lourenço, Eleanor R. Watkins, Uri Obolski, Samuel J. Peacock, Callum Morris, Martin C. J. Maiden, Sunetra Gupta
bioRxiv 082990; doi: https://doi.org/10.1101/082990

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Epidemiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4687)
  • Biochemistry (10371)
  • Bioengineering (7690)
  • Bioinformatics (26364)
  • Biophysics (13545)
  • Cancer Biology (10715)
  • Cell Biology (15456)
  • Clinical Trials (138)
  • Developmental Biology (8509)
  • Ecology (12837)
  • Epidemiology (2067)
  • Evolutionary Biology (16879)
  • Genetics (11409)
  • Genomics (15489)
  • Immunology (10633)
  • Microbiology (25243)
  • Molecular Biology (10233)
  • Neuroscience (54567)
  • Paleontology (402)
  • Pathology (1671)
  • Pharmacology and Toxicology (2899)
  • Physiology (4350)
  • Plant Biology (9263)
  • Scientific Communication and Education (1587)
  • Synthetic Biology (2558)
  • Systems Biology (6787)
  • Zoology (1470)