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Compromised External Validity: Federally Produced Cannabis Does Not Reflect Legal Markets

Daniela Vergara, L. Cinnamon Bidwell, Reggie Gaudino, Anthony Torres, Gary Du, Travis C. Ruthenburg, Kymron deCesare, Donald P. Land, Kent E. Hutchison, Nolan C. Kane
doi: https://doi.org/10.1101/083444
Daniela Vergara
1University of Colorado Boulder, Department of Ecology and Evolutionary Biology
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  • For correspondence: daniela.vergara@colorado.edu nolan.kane@colorado.edu
L. Cinnamon Bidwell
2University of Colorado Boulder, Institute of Cognitive Science
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Reggie Gaudino
3Steep Hill Labs Inc. 1005 Parker Street, Berkeley, CA 94710
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Anthony Torres
3Steep Hill Labs Inc. 1005 Parker Street, Berkeley, CA 94710
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Gary Du
3Steep Hill Labs Inc. 1005 Parker Street, Berkeley, CA 94710
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Travis C. Ruthenburg
3Steep Hill Labs Inc. 1005 Parker Street, Berkeley, CA 94710
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Kymron deCesare
3Steep Hill Labs Inc. 1005 Parker Street, Berkeley, CA 94710
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Donald P. Land
3Steep Hill Labs Inc. 1005 Parker Street, Berkeley, CA 94710
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Kent E. Hutchison
4University of Colorado Boulder, Department of Psychology and Neuroscience
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Nolan C. Kane
1University of Colorado Boulder, Department of Ecology and Evolutionary Biology
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  • For correspondence: daniela.vergara@colorado.edu nolan.kane@colorado.edu
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Abstract

As the most widely used illicit drug, the basis of the fastest growing major industry in the US, and as a source of numerous under-studied psychoactive compounds, understanding the psychological and physiological effects of Cannabis is essential. The National Institute on Drug Abuse (NIDA) is designated as the sole legal producer of Cannabis for use in US research studies. We sought to compare the chemical profiles of Cannabis varieties that are available to consumers in states that have state-legalized use versus what is available to researchers interested in studying the plant and its effects. Our results demonstrate that the federally produced Cannabis has significantly less variety and lower concentrations of cannabinoids. Current research, which has focused on material that is far less diverse and less potent than that used by the public, limits our understanding of the plant’s chemical, biological, psychological, medical, and pharmacological properties. Investigation is urgently needed on the diverse forms of Cannabis used by the public in state-legal markets.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 26, 2016.
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Compromised External Validity: Federally Produced Cannabis Does Not Reflect Legal Markets
Daniela Vergara, L. Cinnamon Bidwell, Reggie Gaudino, Anthony Torres, Gary Du, Travis C. Ruthenburg, Kymron deCesare, Donald P. Land, Kent E. Hutchison, Nolan C. Kane
bioRxiv 083444; doi: https://doi.org/10.1101/083444
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Compromised External Validity: Federally Produced Cannabis Does Not Reflect Legal Markets
Daniela Vergara, L. Cinnamon Bidwell, Reggie Gaudino, Anthony Torres, Gary Du, Travis C. Ruthenburg, Kymron deCesare, Donald P. Land, Kent E. Hutchison, Nolan C. Kane
bioRxiv 083444; doi: https://doi.org/10.1101/083444

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