Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

Daniel J. Weiner; Emilie M. Wigdor; Stephan Ripke; Raymond K. Walters; Jack A. Kosmicki; Jakob Grove; Kaitlin E. Samocha; Jacqueline Goldstein; Aysu Okbay; Jonas Bybjerg-Gauholm; Thomas Werge; David M. Hougaard; Jacob Taylor; David Skuse; Bernie Devlin; Richard Anney; Stephan Sanders; Somer Bishop; Preben Bo Mortensen; Anders D. Børglum; George Davey Smith; Mark J. Daly; Elise B. Robinson; iPSYCH-Broad Autism Group; Psychiatric Genomics Consortium Autism Group; Psychiatric Genomics Consortium Autism Group

doi:10.1101/089342

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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

Daniel J. Weiner, Emilie M. Wigdor, Stephan Ripke, Raymond K. Walters, Jack A. Kosmicki, Jakob Grove, Kaitlin E. Samocha, Jacqueline Goldstein, Aysu Okbay, Jonas Bybjerg-Gauholm, Thomas Werge, David M. Hougaard, Jacob Taylor, David Skuse, Bernie Devlin, Richard Anney, Stephan Sanders, Somer Bishop, Preben Bo Mortensen, Anders D. Børglum, George Davey Smith, Mark J. Daly, Elise B. Robinson, iPSYCH-Broad Autism Group, Psychiatric Genomics Consortium Autism Group, Psychiatric Genomics Consortium Autism Group

doi: https://doi.org/10.1101/089342

Daniel J. Weiner

Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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Emilie M. Wigdor

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Stephan Ripke

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Raymond K. Walters

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Jack A. Kosmicki

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Jakob Grove

Department of Biomedicine (Human Genetics), Aarhus University, Aarhus, Denmark.Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark.Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.

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Kaitlin E. Samocha

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Jacqueline Goldstein

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Aysu Okbay

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, 1081 HV, The Netherlands.

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Jonas Bybjerg-Gauholm

Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark.Danish Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.

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Thomas Werge

Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark.Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Copenhagen, Denmark.Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

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David M. Hougaard

Danish Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.

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Jacob Taylor

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David Skuse

Behavioural Sciences Unit, Institute of Child Health, University College London, London, UK.

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Bernie Devlin

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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Richard Anney

Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales, UK.

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Stephan Sanders

Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA.

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Somer Bishop

Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA.

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Preben Bo Mortensen

Department of Biomedicine (Human Genetics), Aarhus University, Aarhus, Denmark.Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark.National Centre for Register-based Research, University of Aarhus, Aarhus, Denmark.

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Anders D. Børglum

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George Davey Smith

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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Mark J. Daly

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Elise B. Robinson

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For correspondence: erob@broadinstitute.org

For correspondence: pgc.autism@gmail.com

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