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Structural covariance networks across the lifespan, from 6-94 years of age

View ORCID ProfileElizabeth DuPre, View ORCID ProfileR. Nathan Spreng
doi: https://doi.org/10.1101/090233
Elizabeth DuPre
Laboratory of Brain and Cognition, Human Neuroscience Institute, Department of Human Development, Cornell University, Ithaca NY, USA
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R. Nathan Spreng
Laboratory of Brain and Cognition, Human Neuroscience Institute, Department of Human Development, Cornell University, Ithaca NY, USA
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Abstract

Structural covariance examines covariation of grey matter morphology between brain regions and across individuals. Despite significant interest in the influence of age on structural covariance patterns, no study to date has provided a complete lifespan perspective—bridging childhood with early, middle, and late adulthood—on the development of structural covariance networks. Here, we investigate the lifespan trajectories of structural covariance in six canonical neurocognitive networks: default, dorsal attention, frontoparietal control, somatomotor, ventral attention, and visual. By combining data from five open access data sources, we examine the structural covariance trajectories of these networks from 6-94 years of age in a sample of 1580 participants. Using partial least squares, we show that structural covariance patterns across the lifespan exhibit two significant, age-dependent trends. The first trend is a stable pattern whose integrity declines over the lifespan. The second trend is an inverted-U that differentiates young adulthood from other age groups. Hub regions, including posterior cingulate cortex and anterior insula, appear particularly influential in the expression of this second age-dependent trend. Overall, our results suggest that structural covariance provides a reliable definition of neurocognitive networks across the lifespan and reveal both shared and network-specific trajectories.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 11, 2017.
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Structural covariance networks across the lifespan, from 6-94 years of age
Elizabeth DuPre, R. Nathan Spreng
bioRxiv 090233; doi: https://doi.org/10.1101/090233
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Structural covariance networks across the lifespan, from 6-94 years of age
Elizabeth DuPre, R. Nathan Spreng
bioRxiv 090233; doi: https://doi.org/10.1101/090233

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