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NLR signaling network mediates immunity to diverse plant pathogens

Chih-Hang Wu, Ahmed Abd-El-Haliem, Tolga O. Bozkurt, Khaoula Belhaj, Ryohei Terauchi, Jack H. Vossen, View ORCID ProfileSophien Kamoun
doi: https://doi.org/10.1101/090449
Chih-Hang Wu
1The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.
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Ahmed Abd-El-Haliem
2Plant Breeding, Wageningen University and Research, Wageningen, The Netherlands.
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Tolga O. Bozkurt
1The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.
3Department of Life Sciences, Imperial College London, London, United Kingdom.
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Khaoula Belhaj
1The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.
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Ryohei Terauchi
4Iwate Biotechnology Research Center, Iwate, Japan.
5Kyoto University, Kyoto, Japan
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Jack H. Vossen
2Plant Breeding, Wageningen University and Research, Wageningen, The Netherlands.
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Sophien Kamoun
1The Sainsbury Laboratory, Norwich Research Park, Norwich, United Kingdom.
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  • ORCID record for Sophien Kamoun
  • For correspondence: sophien.kamoun@tsl.ac.uk
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Abstract

Plant and animal nucleotide-binding domain and leucine-rich repeat-containing (NLR) proteins often function in pairs to mediate innate immunity to pathogens. However, the degree to which NLR proteins form signaling networks beyond genetically linked pairs is poorly understood. In this study, we discovered that a large NLR immune signaling network with a complex genetic architecture confers immunity to oomycetes, bacteria, viruses, nematodes, and insects. The network emerged over 100 million years ago from a linked NLR pair that diversified into up to one half of the NLR of asterid plants. We propose that this NLR network increases robustness of immune signaling to counteract rapidly evolving plant pathogens.

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Posted November 29, 2016.
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NLR signaling network mediates immunity to diverse plant pathogens
Chih-Hang Wu, Ahmed Abd-El-Haliem, Tolga O. Bozkurt, Khaoula Belhaj, Ryohei Terauchi, Jack H. Vossen, Sophien Kamoun
bioRxiv 090449; doi: https://doi.org/10.1101/090449
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NLR signaling network mediates immunity to diverse plant pathogens
Chih-Hang Wu, Ahmed Abd-El-Haliem, Tolga O. Bozkurt, Khaoula Belhaj, Ryohei Terauchi, Jack H. Vossen, Sophien Kamoun
bioRxiv 090449; doi: https://doi.org/10.1101/090449

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