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Genomic analysis of Mycobacterium tuberculosis reveals complex etiology of tuberculosis in Vietnam including frequent introduction and transmission of Beijing lineage and positive selection for EsxW Beijing variant

Kathryn E Holt, Paul McAdam, Phan Vuong Khac Thai, Dang Thi Minh Ha, Nguyen Ngoc Lan, Nguyen Huu Lan, Nguyen Thi Quynh Nhu, Nguyen Thuy Thuong Thuong, Guy Thwaites, David J Edwards, Kym Pham, Jeremy Farrar, Chiea Chuen Khor, Yik Ying Teo, Michael Inouye, Maxine Caws, Sarah J Dunstan
doi: https://doi.org/10.1101/092189
Kathryn E Holt
1Centre for Systems Genomics, University of Melbourne, Parkville, Victoria 3010, Australia
2Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
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  • For correspondence: kholt@unimelb.edu.au sarah.dunstan@unimelb.edu.au
Paul McAdam
2Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
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Phan Vuong Khac Thai
3Pham Ngoc Thach Hospital for Tuberculosis and Lung Disease, Ho Chi Minh City, District 5, Viet Nam
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Dang Thi Minh Ha
3Pham Ngoc Thach Hospital for Tuberculosis and Lung Disease, Ho Chi Minh City, District 5, Viet Nam
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Nguyen Ngoc Lan
3Pham Ngoc Thach Hospital for Tuberculosis and Lung Disease, Ho Chi Minh City, District 5, Viet Nam
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Nguyen Huu Lan
3Pham Ngoc Thach Hospital for Tuberculosis and Lung Disease, Ho Chi Minh City, District 5, Viet Nam
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Nguyen Thi Quynh Nhu
4Oxford University Clinical Research Unit, Ho Chi Minh City, District 5, Viet Nam
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Nguyen Thuy Thuong Thuong
4Oxford University Clinical Research Unit, Ho Chi Minh City, District 5, Viet Nam
5Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.
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Guy Thwaites
4Oxford University Clinical Research Unit, Ho Chi Minh City, District 5, Viet Nam
5Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.
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David J Edwards
1Centre for Systems Genomics, University of Melbourne, Parkville, Victoria 3010, Australia
2Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
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Kym Pham
6Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia
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Jeremy Farrar
4Oxford University Clinical Research Unit, Ho Chi Minh City, District 5, Viet Nam
5Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.
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Chiea Chuen Khor
7Genome Institute of Singapore, Singapore
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Yik Ying Teo
8Department of Statistics and Applied Probability, National University of Singapore, Singapore.
9Saw Swee Hock School of Public Health, National University of Singapore, Singapore
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Michael Inouye
1Centre for Systems Genomics, University of Melbourne, Parkville, Victoria 3010, Australia
10School of BioSciences, University of Melbourne, Parkville, Victoria 3010, Australia
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Maxine Caws
11Liverpool School of Tropical Medicine, Liverpool, UK
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Sarah J Dunstan
12Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia
1Centre for Systems Genomics, University of Melbourne, Parkville, Victoria 3010, Australia
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  • For correspondence: kholt@unimelb.edu.au sarah.dunstan@unimelb.edu.au
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Posted December 07, 2016.
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Genomic analysis of Mycobacterium tuberculosis reveals complex etiology of tuberculosis in Vietnam including frequent introduction and transmission of Beijing lineage and positive selection for EsxW Beijing variant
Kathryn E Holt, Paul McAdam, Phan Vuong Khac Thai, Dang Thi Minh Ha, Nguyen Ngoc Lan, Nguyen Huu Lan, Nguyen Thi Quynh Nhu, Nguyen Thuy Thuong Thuong, Guy Thwaites, David J Edwards, Kym Pham, Jeremy Farrar, Chiea Chuen Khor, Yik Ying Teo, Michael Inouye, Maxine Caws, Sarah J Dunstan
bioRxiv 092189; doi: https://doi.org/10.1101/092189
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Genomic analysis of Mycobacterium tuberculosis reveals complex etiology of tuberculosis in Vietnam including frequent introduction and transmission of Beijing lineage and positive selection for EsxW Beijing variant
Kathryn E Holt, Paul McAdam, Phan Vuong Khac Thai, Dang Thi Minh Ha, Nguyen Ngoc Lan, Nguyen Huu Lan, Nguyen Thi Quynh Nhu, Nguyen Thuy Thuong Thuong, Guy Thwaites, David J Edwards, Kym Pham, Jeremy Farrar, Chiea Chuen Khor, Yik Ying Teo, Michael Inouye, Maxine Caws, Sarah J Dunstan
bioRxiv 092189; doi: https://doi.org/10.1101/092189

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