Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Import and Export of Gold Nanoparticles: Exchange Rate in Cancer Cells and Fibroblasts

View ORCID ProfileVladimir Ivošev, Gloria Jiménez Sánchez, Darine Abi Haidar, Rana Bazzi, Stéphane Roux, Sandrine Lacombe
doi: https://doi.org/10.1101/092601
Vladimir Ivošev
Institute of Molecular Sciences (ISMO), UMR 8625, University Paris-Saclay, CNRS, 91405 Orsay Cedex, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Vladimir Ivošev
Gloria Jiménez Sánchez
Institute UTINAM, UMR 6213, CNRS-UFC, University of Bourgogne Franche-Comte, Besançon Cedex, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Darine Abi Haidar
IMNC Laboratory, UMR 8165-CNRS/ IN2P3, University Paris-Saclay, 91405 Orsay, FranceParis Diderot University, Sorbonne Paris Cité, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rana Bazzi
Institute UTINAM, UMR 6213, CNRS-UFC, University of Bourgogne Franche-Comte, Besançon Cedex, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stéphane Roux
Institute UTINAM, UMR 6213, CNRS-UFC, University of Bourgogne Franche-Comte, Besançon Cedex, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sandrine Lacombe
Institute of Molecular Sciences (ISMO), UMR 8625, University Paris-Saclay, CNRS, 91405 Orsay Cedex, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Cancer is one of the leading causes of death. Radiation therapy is an important modality used in cancer treatment being highly cost-effective. Major flaw of radiotherapy is lack of selectivity between cancerous and healthy tissues. Amelioration of radiotherapy by using high-Z nanoparticles as radiation enhancers is one of potential solutions. Gold nanoparticles (AuNPs) are commonly used as radioenhancers. Understanding the interaction between cancer cells and AuNPs is essential in order to achieve best possible radioenhancing effects, while sparing healthy tissues. This work aims to elucidate interactions of ultrasmall (core size: 2.4 nm and hydrodynamic diameter (Dh): 4.5 nm) fluorescently labeled AuNPs with various human cell lines. In this perspective we measured uptake dynamics, characterized route of internalization and time of intracellular retention in various cancer cell lines and fibroblasts. Our results show that uptake dynamics and internalization pathways are strongly cell line-dependant. We also demonstrate that higher proportion of internalized nanoparticles resides in cancer cells, compared to fibroblasts, in in vitro conditions. This work highlights great complexity of cancerous cells and underlines the necessity for excellent knowledge of biological behaviour for each type of cancer. It also emphasizes the major effort needed for efficient cancer treatments and makes an appeal for further development of highly selective nanoparticles in order to hasten their utilization in clinical conditions.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted December 08, 2016.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Import and Export of Gold Nanoparticles: Exchange Rate in Cancer Cells and Fibroblasts
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Import and Export of Gold Nanoparticles: Exchange Rate in Cancer Cells and Fibroblasts
Vladimir Ivošev, Gloria Jiménez Sánchez, Darine Abi Haidar, Rana Bazzi, Stéphane Roux, Sandrine Lacombe
bioRxiv 092601; doi: https://doi.org/10.1101/092601
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Import and Export of Gold Nanoparticles: Exchange Rate in Cancer Cells and Fibroblasts
Vladimir Ivošev, Gloria Jiménez Sánchez, Darine Abi Haidar, Rana Bazzi, Stéphane Roux, Sandrine Lacombe
bioRxiv 092601; doi: https://doi.org/10.1101/092601

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Cell Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (1544)
  • Biochemistry (2500)
  • Bioengineering (1757)
  • Bioinformatics (9727)
  • Biophysics (3928)
  • Cancer Biology (2990)
  • Cell Biology (4235)
  • Clinical Trials (135)
  • Developmental Biology (2653)
  • Ecology (4129)
  • Epidemiology (2033)
  • Evolutionary Biology (6931)
  • Genetics (5243)
  • Genomics (6531)
  • Immunology (2207)
  • Microbiology (7012)
  • Molecular Biology (2782)
  • Neuroscience (17410)
  • Paleontology (127)
  • Pathology (432)
  • Pharmacology and Toxicology (712)
  • Physiology (1068)
  • Plant Biology (2515)
  • Scientific Communication and Education (647)
  • Synthetic Biology (835)
  • Systems Biology (2698)
  • Zoology (439)