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Same-day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples

Antonina A. Votintseva, Phelim Bradley, Louise Pankhurst, Carlos del Ojo Elias, Matthew Loose, Kayzad Nilgiriwala, Anirvan Chatterjee, E. Grace Smith, Nicholas Sanderson, Timothy M. Walker, Marcus R. Morgan, David H. Wyllie, A. Sarah Walker, Tim E. A. Peto, Derrick W. Crook, View ORCID ProfileZamin Iqbal
doi: https://doi.org/10.1101/094789
Antonina A. Votintseva
1Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
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  • For correspondence: a.votintseva@gmail.com zam@well.ox.ac.uk
Phelim Bradley
2Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
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Louise Pankhurst
1Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
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Carlos del Ojo Elias
2Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
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Matthew Loose
3School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH
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Kayzad Nilgiriwala
4Foundation for Medical Research, Mumbai
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Anirvan Chatterjee
4Foundation for Medical Research, Mumbai
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E. Grace Smith
5Regional Centre for Mycobacteriology, PHE Public Health Laboratory Birmingham. Heartlands Hospital, Birmingham B9 5SS, UK
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Nicholas Sanderson
1Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
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Timothy M. Walker
1Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
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Marcus R. Morgan
6Microbiology Laboratory, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, United Kingdom
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David H. Wyllie
1Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
7The Jenner Institute, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom
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A. Sarah Walker
1Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
8National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
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Tim E. A. Peto
1Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
8National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
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Derrick W. Crook
1Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
8National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
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Zamin Iqbal
2Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
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  • ORCID record for Zamin Iqbal
  • For correspondence: a.votintseva@gmail.com zam@well.ox.ac.uk
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Article Information

doi 
https://doi.org/10.1101/094789
History 
  • December 19, 2016.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Antonina A. Votintseva1,#★,
  2. Phelim Bradley2★,
  3. Louise Pankhurst1★,
  4. Carlos del Ojo Elias2,
  5. Matthew Loose3,
  6. Kayzad Nilgiriwala4,
  7. Anirvan Chatterjee4,
  8. E. Grace Smith5,
  9. Nicholas Sanderson1,
  10. Timothy M. Walker1,
  11. Marcus R. Morgan6,
  12. David H. Wyllie1,7,
  13. A. Sarah Walker1,8,
  14. Tim E. A. Peto1,8,
  15. Derrick W. Crook1,8+ and
  16. Zamin Iqbal2+#
  1. 1Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
  2. 2Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
  3. 3School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH
  4. 4Foundation for Medical Research, Mumbai
  5. 5Regional Centre for Mycobacteriology, PHE Public Health Laboratory Birmingham. Heartlands Hospital, Birmingham B9 5SS, UK
  6. 6Microbiology Laboratory, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, United Kingdom
  7. 7The Jenner Institute, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom
  8. 8National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
  1. ↵#Corresponding authors; Dr Antonina A. Votintseva; Address: Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Level 7, Oxford, OX3 9DU, United Kingdom Kingdom1. Email: a.votintseva{at}gmail.com, Dr Zamin Iqbal; Address: Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN. Email: zam{at}well.ox.ac.uk
  1. ↵+ These authors contributed equally

  2. ↵★ These authors contributed equally

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Same-day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples
Antonina A. Votintseva, Phelim Bradley, Louise Pankhurst, Carlos del Ojo Elias, Matthew Loose, Kayzad Nilgiriwala, Anirvan Chatterjee, E. Grace Smith, Nicholas Sanderson, Timothy M. Walker, Marcus R. Morgan, David H. Wyllie, A. Sarah Walker, Tim E. A. Peto, Derrick W. Crook, Zamin Iqbal
bioRxiv 094789; doi: https://doi.org/10.1101/094789
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Same-day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples
Antonina A. Votintseva, Phelim Bradley, Louise Pankhurst, Carlos del Ojo Elias, Matthew Loose, Kayzad Nilgiriwala, Anirvan Chatterjee, E. Grace Smith, Nicholas Sanderson, Timothy M. Walker, Marcus R. Morgan, David H. Wyllie, A. Sarah Walker, Tim E. A. Peto, Derrick W. Crook, Zamin Iqbal
bioRxiv 094789; doi: https://doi.org/10.1101/094789

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