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Environment determines evolutionary trajectory in a constrained phenotypic space

David T. Fraebel, Harry Mickalide, Diane Schnitkey, Jason Merritt, Thomas E Kuhlman, View ORCID ProfileSeppe Kuehn
doi: https://doi.org/10.1101/096909
David T. Fraebel
1Center for the Physics of Living Cells. University of Illinois at Urbana-Champaign, Urbana, IL 61801.;
3Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
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Harry Mickalide
1Center for the Physics of Living Cells. University of Illinois at Urbana-Champaign, Urbana, IL 61801.;
3Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
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Diane Schnitkey
1Center for the Physics of Living Cells. University of Illinois at Urbana-Champaign, Urbana, IL 61801.;
3Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
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Jason Merritt
1Center for the Physics of Living Cells. University of Illinois at Urbana-Champaign, Urbana, IL 61801.;
3Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
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Thomas E Kuhlman
1Center for the Physics of Living Cells. University of Illinois at Urbana-Champaign, Urbana, IL 61801.;
2Center for Biophysics and Quantitative Biology. University of Illinois at Urbana-Champaign, Urbana, IL 61801.;
3Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
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Seppe Kuehn
1Center for the Physics of Living Cells. University of Illinois at Urbana-Champaign, Urbana, IL 61801.;
2Center for Biophysics and Quantitative Biology. University of Illinois at Urbana-Champaign, Urbana, IL 61801.;
3Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801.
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  • ORCID record for Seppe Kuehn
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Abstract

Constraints on phenotypic variation limit the capacity of organisms to adapt to the multiple selection pressures encountered in natural environments. To better understand evolutionary dynamics in this context, we select Escherichia coli for faster migration through a porous environment, a process which depends on both motility and growth. We find that a trade-off between swimming speed and growth rate constrains the evolution of faster migration. Evolving faster migration in rich medium results in slow growth and fast swimming, while evolution in minimal medium results in fast growth and slow swimming. In each condition parallel genomic evolution drives adaptation through different mutations. We show that the trade-off is mediated by antagonistic pleiotropy through mutations that affect negative regulation. A model of the evolutionary process shows that the genetic capacity of an organism to vary traits can qualitatively alter the evolutionary trajectory when selection pressures are complex.

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Posted December 27, 2016.
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Environment determines evolutionary trajectory in a constrained phenotypic space
David T. Fraebel, Harry Mickalide, Diane Schnitkey, Jason Merritt, Thomas E Kuhlman, Seppe Kuehn
bioRxiv 096909; doi: https://doi.org/10.1101/096909
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Environment determines evolutionary trajectory in a constrained phenotypic space
David T. Fraebel, Harry Mickalide, Diane Schnitkey, Jason Merritt, Thomas E Kuhlman, Seppe Kuehn
bioRxiv 096909; doi: https://doi.org/10.1101/096909

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