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Demonstration of short-term plasticity in the dorsolateral prefrontal cortex with theta burst stimulation: A TMS-EEG study

Sung Wook Chung, Benjamin P. Lewis, Nigel C. Rogasch, Takashi Saeki, Richard H. Thomson, Kate E. Hoy, Neil W. Bailey, Paul B. Fitzgerald
doi: https://doi.org/10.1101/101097
Sung Wook Chung
1Monash Alfred Psychiatry Research Centre, Monash University, Central Clinical School and The Alfred, Melbourne, Australia
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Benjamin P. Lewis
1Monash Alfred Psychiatry Research Centre, Monash University, Central Clinical School and The Alfred, Melbourne, Australia
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Nigel C. Rogasch
2Brain and Mental Health Laboratory, School of Psychological Sciences and Monash Biomedical Imaging, Monash Institute of Cognitive and Clinical Neuroscience, Monash University, Melbourne, Australia
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Takashi Saeki
1Monash Alfred Psychiatry Research Centre, Monash University, Central Clinical School and The Alfred, Melbourne, Australia
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Richard H. Thomson
1Monash Alfred Psychiatry Research Centre, Monash University, Central Clinical School and The Alfred, Melbourne, Australia
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Kate E. Hoy
1Monash Alfred Psychiatry Research Centre, Monash University, Central Clinical School and The Alfred, Melbourne, Australia
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Neil W. Bailey
2Brain and Mental Health Laboratory, School of Psychological Sciences and Monash Biomedical Imaging, Monash Institute of Cognitive and Clinical Neuroscience, Monash University, Melbourne, Australia
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Paul B. Fitzgerald
1Monash Alfred Psychiatry Research Centre, Monash University, Central Clinical School and The Alfred, Melbourne, Australia
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Abstract

Objectives To examine the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) on cortical reactivity in the dorsolateral prefrontal cortex.

Methods 10 healthy participants were stimulated with either iTBS, cTBS or sham at F3 electrode. Single- and paired-pulse TMS and concurrent electroencephalography (EEG) were used to assess change in cortical reactivity and long-interval intracortical inhibition (LICI) via TMS-evoked potentials (TEPs) and TMS-evoked oscillations.

Results Significant increases in N120 amplitudes (p < 0.01) were observed following iTBS over prefrontal cortex. Changes in TMS-evoked theta oscillations and LICI of theta oscillations were also observed following iTBS (increase) and cTBS (decrease). Change in LICI of theta oscillations correlated with change in N120 amplitude following TBS (r = −0.670, p = 0.001).

Conclusions This study provides preliminary evidence that TBS produces direct changes in cortical reactivity in the prefrontal cortex. Combining TBS with TMS-EEG may be a useful approach to optimise stimulation paradigms prior to the conduct of clinical trials.

Significance TBS is able to modulate cortical reactivity and cortical inhibition in the prefrontal cortex.

Highlights

  • Effects of iTBS and cTBS were studied in the DLPFC using TMS-EEG

  • iTBS increased N120 amplitude, theta power and LICI of theta

  • cTBS decreased theta power alone

Footnotes

  • Disclosures and conflict of interests: SWC was supported by a Monash Graduate Scholarship. NCR is supported by a NHMRC Early Career Fellowship (1072057). KEH is supported by a NHMRC Career Development Fellowship (1082894). PBF is supported by a NHMRC Practitioner Fellowship (1078567). PBF has received equipment for research from MagVenture A/S, Medtronic Ltd, Cervel Neurotech and Brainsway Ltd and funding for research from Neuronetics and Cervel Neurotech. He is on the scientific advisory board for Bionomics Ltd. There are no other conflicts.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted January 17, 2017.
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Demonstration of short-term plasticity in the dorsolateral prefrontal cortex with theta burst stimulation: A TMS-EEG study
Sung Wook Chung, Benjamin P. Lewis, Nigel C. Rogasch, Takashi Saeki, Richard H. Thomson, Kate E. Hoy, Neil W. Bailey, Paul B. Fitzgerald
bioRxiv 101097; doi: https://doi.org/10.1101/101097
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Demonstration of short-term plasticity in the dorsolateral prefrontal cortex with theta burst stimulation: A TMS-EEG study
Sung Wook Chung, Benjamin P. Lewis, Nigel C. Rogasch, Takashi Saeki, Richard H. Thomson, Kate E. Hoy, Neil W. Bailey, Paul B. Fitzgerald
bioRxiv 101097; doi: https://doi.org/10.1101/101097

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