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Warburg-like metabolism coordinates FGF and Wnt signaling in the vertebrate embryo

Masayuki Oginuma, View ORCID ProfilePhilippe Moncuquet, View ORCID ProfileFengzhu Xiong, View ORCID ProfileEdward Karoly, Jérome Chal, Karine Guevorkian, View ORCID ProfileOlivier Pourquié
doi: https://doi.org/10.1101/101451
Masayuki Oginuma
1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Université de Strasbourg, Illkirch. F-67400, France.
2Department of Genetics, Harvard Medical School and Department of Pathology, Brigham and Woman’s Hospital. 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
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Philippe Moncuquet
1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Université de Strasbourg, Illkirch. F-67400, France.
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Fengzhu Xiong
2Department of Genetics, Harvard Medical School and Department of Pathology, Brigham and Woman’s Hospital. 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
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Edward Karoly
3Metabolon, Morrisville, NC, USA.
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Jérome Chal
1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Université de Strasbourg, Illkirch. F-67400, France.
2Department of Genetics, Harvard Medical School and Department of Pathology, Brigham and Woman’s Hospital. 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
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Karine Guevorkian
1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Université de Strasbourg, Illkirch. F-67400, France.
2Department of Genetics, Harvard Medical School and Department of Pathology, Brigham and Woman’s Hospital. 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
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Olivier Pourquié
1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Université de Strasbourg, Illkirch. F-67400, France.
2Department of Genetics, Harvard Medical School and Department of Pathology, Brigham and Woman’s Hospital. 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
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Abstract

Mammalian embryos transiently exhibit aerobic glycolysis (Warburg effect), a metabolic adaptation also observed in cancer cells. The role of this particular type of metabolism during vertebrate organogenesis is currently unknown. Here, we provide evidence for spatio-temporal regulation of aerobic glycolysis in the posterior region of mouse and chicken embryos. We show that a posterior glycolytic gradient is established in response to graded transcription of glycolytic enzymes downstream of FGF signaling. We demonstrate that glycolysis controls posterior elongation of the embryonic axis by regulating cell motility in the presomitic mesoderm and by controlling specification of the paraxial mesoderm fate in the tail bud. Our results suggest that Warburg metabolism in the tail bud coordinates Wnt and FGF signaling to promote elongation of the embryonic axis.

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Posted January 18, 2017.
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Warburg-like metabolism coordinates FGF and Wnt signaling in the vertebrate embryo
Masayuki Oginuma, Philippe Moncuquet, Fengzhu Xiong, Edward Karoly, Jérome Chal, Karine Guevorkian, Olivier Pourquié
bioRxiv 101451; doi: https://doi.org/10.1101/101451
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Warburg-like metabolism coordinates FGF and Wnt signaling in the vertebrate embryo
Masayuki Oginuma, Philippe Moncuquet, Fengzhu Xiong, Edward Karoly, Jérome Chal, Karine Guevorkian, Olivier Pourquié
bioRxiv 101451; doi: https://doi.org/10.1101/101451

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