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Literature Consistency of Bioinformatics Sequence Databases is Effective for Assessing Record Quality

View ORCID ProfileMohamed Reda Bouadjenek, View ORCID ProfileKarin Verspoor, View ORCID ProfileJustin Zobel
doi: https://doi.org/10.1101/101873
Mohamed Reda Bouadjenek
University of Melbourne, Australia
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Karin Verspoor
University of Melbourne, Australia
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Justin Zobel
University of Melbourne, Australia
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Abstract

Bioinformatics sequence databases such as Genbank or UniProt contain hundreds of millions of records of genomic data. These records are derived from direct submissions from individual laboratories, as well as from bulk submissions from large-scale sequencing centres; their diversity and scale means that they suffer from a range of data quality issues including errors, discrepancies, redundancies, ambiguities, incompleteness, and inconsistencies with the published literature. In this work, we seek to investigate and analyze the data quality of sequence databases from the perspective of a curator, who must detect anomalous and suspicious records.

Specifically, we emphasize the detection of inconsistent records with respect to the literature. Focusing on GenBank, we propose a set of 24 quality indicators, which are based on treating a record as a query into the published literature, and then use query quality predictors. We then carry out an analysis that shows that the proposed quality indicators and the quality of the records have a mutual relationship, in which one depends on the other. We propose to represent record-literature consistency as a vector of these quality indicators. By reducing the dimensionality of this representation for visualization purposes using Principal Component Analysis, we show that records which have been reported as inconsistent with the literature fall roughly in the same area, and therefore share similar characteristics. By manually analyzing records not previously known to be erroneous that fall in the same area than records know to be inconsistent, we show that 1 record out of 4 is inconsistent with respect to the literature. This high density of inconsistent record opens the way towards the development of automatic methods for the detection of faulty records. We conclude that literature inconsistency is a meaningful strategy for identifying suspicious records.

Footnotes

  • reda.bouadjenek{at}unimelb.edu.au, karin.verspoor{at}unimelb.edu.au, jzobel{at}unimelb.edu.au

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted February 23, 2017.
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Literature Consistency of Bioinformatics Sequence Databases is Effective for Assessing Record Quality
Mohamed Reda Bouadjenek, Karin Verspoor, Justin Zobel
bioRxiv 101873; doi: https://doi.org/10.1101/101873
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Literature Consistency of Bioinformatics Sequence Databases is Effective for Assessing Record Quality
Mohamed Reda Bouadjenek, Karin Verspoor, Justin Zobel
bioRxiv 101873; doi: https://doi.org/10.1101/101873

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