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Cinnamon hydro alcoholic extract increased expression level of UCP3 gene in skeletal muscle of obese male Wistar Rats

Elham Golmohamadi, Sanaz Mahmazi, Medi Rahnema
doi: https://doi.org/10.1101/105155
Elham Golmohamadi
1MSc student, Department of genetics, Faculty of basic Sciences, Islamic Azad University, Zanjan Branch, zanjan, Iran
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Sanaz Mahmazi
2Assistant Professor, Department of genetics, Faculty of basic Sciences, Islamic Azad University, Zanjan Branch, zanjan, Iran
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Medi Rahnema
3Associate Professor, Department of physiology, Faculty of basic Sciences, Islamic Azad University, Zanjan Branch, zanjan, Iran
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abstract

UCPs are the mitochondrial inner membrane proteins regulating basal metabolism. Ucp3 in muscle and adipose tissue helping metabolism and fat oxidation affecting thermogenesis, involve in fatty acid metabolism and energy homeostasis.

42 adult rats divided into 6 groups including control group, the high-fat diet Obese group, experimental groups that in addition to the high-fat diet received 50,100,200 mgKg-1 doses of cinnamon extract and the sham group with 200 mgKg-1 extract treatment. RNA extracted from muscles, cDNA synthesized and Ucp3 gene expression level was examined by real-time PCR.

In Obese rats’ muscle, significant decrease in UCP3 gene expression was observed but in exprimental groups there was significant increased level of UCP3 gene expression in 100, 50 mgKg-1 dose of treatment.

UCP3 might be a target for pharmacological up regulation in treatment of obesity. Cinnamon might influence UCP3 expression, in a dose dependent manner and low dose was more effective.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted February 02, 2017.
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Cinnamon hydro alcoholic extract increased expression level of UCP3 gene in skeletal muscle of obese male Wistar Rats
Elham Golmohamadi, Sanaz Mahmazi, Medi Rahnema
bioRxiv 105155; doi: https://doi.org/10.1101/105155
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Cinnamon hydro alcoholic extract increased expression level of UCP3 gene in skeletal muscle of obese male Wistar Rats
Elham Golmohamadi, Sanaz Mahmazi, Medi Rahnema
bioRxiv 105155; doi: https://doi.org/10.1101/105155

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