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Holotomography: refractive index as an intrinsic imaging contrast for 3-D label-free live cell imaging

Doyeon Kim, SangYun Lee, Moosung Lee, JunTaek Oh, Su-A Yang, YongKeun Park
doi: https://doi.org/10.1101/106328
Doyeon Kim
1Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea
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SangYun Lee
2Department of Physics, KAIST, Daejeon 34141, South Korea
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Moosung Lee
2Department of Physics, KAIST, Daejeon 34141, South Korea
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JunTaek Oh
2Department of Physics, KAIST, Daejeon 34141, South Korea
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Su-A Yang
3Department of Biological Sciences, KAIST, Daejeon 34141, South Korea
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YongKeun Park
2Department of Physics, KAIST, Daejeon 34141, South Korea
4KAIST Institute Health Science and Technology, Daejeon 34141, South Korea
5Tomocube Inc., Daejeon 34051, South Korea
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  • For correspondence: yk.park@kaist.ac.kr
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Abstract

Live cell imaging provides essential information in the investigation of cell biology and related pathophysiology. Refractive index (RI) can serve as intrinsic optical imaging contrast for 3-D label-free and quantitative live cell imaging, and provide invaluable information to understand various dynamics of cells and tissues for the study of numerous fields. Recently significant advances have been made in imaging methods and analysis approaches utilizing RI, which are now being transferred to biological and medical research fields, providing novel approaches to investigate the pathophysiology of cells. To provide insight how RI can be used as an imaging contrast for imaging of biological specimens, here we provide the basic principle of RI-based imaging techniques and summarize recent progress on applications, ranging from microbiology, hematology, infectious diseases, hematology, and histopathology.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted November 15, 2018.
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Holotomography: refractive index as an intrinsic imaging contrast for 3-D label-free live cell imaging
Doyeon Kim, SangYun Lee, Moosung Lee, JunTaek Oh, Su-A Yang, YongKeun Park
bioRxiv 106328; doi: https://doi.org/10.1101/106328
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Holotomography: refractive index as an intrinsic imaging contrast for 3-D label-free live cell imaging
Doyeon Kim, SangYun Lee, Moosung Lee, JunTaek Oh, Su-A Yang, YongKeun Park
bioRxiv 106328; doi: https://doi.org/10.1101/106328

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