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Salmonella enterica genomes recovered from victims of a major 16th century epidemic in Mexico

Åshild J. Vågene, Michael G. Campana, Nelly M. Robles García, Christina Warinner, Maria A. Spyrou, Aida Andrades Valtueña, Daniel Huson, Noreen Tuross, Alexander Herbig, Kirsten I. Bos, Johannes Krause
doi: https://doi.org/10.1101/106740
Åshild J. Vågene
1Max Planck Institute for the Science of Human History, Jena, Germany.
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Michael G. Campana
2Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
3Institute of Evolutionary Medicine, University of Zurich, Zurich, Switzerland.
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Nelly M. Robles García
4INAH, National Institute of Anthropology and History, Mexico, Teposcolula-Yucundaa Archaeological Project.
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Christina Warinner
1Max Planck Institute for the Science of Human History, Jena, Germany.
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Maria A. Spyrou
1Max Planck Institute for the Science of Human History, Jena, Germany.
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Aida Andrades Valtueña
1Max Planck Institute for the Science of Human History, Jena, Germany.
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Daniel Huson
5Center for Bioinformatics Tübingen (ZBIT), University of Tübingen, Tübingen, Germany.
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Noreen Tuross
2Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
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  • For correspondence: tuross@fas.harvard.edu herbig@shh.mpg.de bos@shh.mpg.de krause@shh.mpg.de
Alexander Herbig
1Max Planck Institute for the Science of Human History, Jena, Germany.
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  • For correspondence: tuross@fas.harvard.edu herbig@shh.mpg.de bos@shh.mpg.de krause@shh.mpg.de
Kirsten I. Bos
1Max Planck Institute for the Science of Human History, Jena, Germany.
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  • For correspondence: tuross@fas.harvard.edu herbig@shh.mpg.de bos@shh.mpg.de krause@shh.mpg.de
Johannes Krause
1Max Planck Institute for the Science of Human History, Jena, Germany.
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  • For correspondence: tuross@fas.harvard.edu herbig@shh.mpg.de bos@shh.mpg.de krause@shh.mpg.de
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Abstract

Indigenous populations of the Americas experienced high mortality rates during the early contact period as a result of infectious diseases, many of which were introduced by Europeans. Most of the pathogenic agents that caused these outbreaks remain unknown. Using a metagenomic tool called MALT to search for traces of ancient pathogen DNA, we were able to identify Salmonella enterica in individuals buried in an early contact era epidemic cemetery at Teposcolula-Yucundaa, Oaxaca in southern Mexico. This cemetery is linked to the 1545-1550 CE epidemic locally known as “cocoliztli”, the cause of which has been debated for over a century. Here we present two reconstructed ancient genomes for Salmonella enterica subsp. enterica serovar Paratyphi C, a bacterial cause of enteric fever. We propose that S. Paratyphi C contributed to the population decline during the 1545 cocoliztli outbreak in Mexico.

One Sentence Summary Genomic evidence of enteric fever identified in an indigenous population from early contact period Mexico.

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Posted February 08, 2017.
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Salmonella enterica genomes recovered from victims of a major 16th century epidemic in Mexico
Åshild J. Vågene, Michael G. Campana, Nelly M. Robles García, Christina Warinner, Maria A. Spyrou, Aida Andrades Valtueña, Daniel Huson, Noreen Tuross, Alexander Herbig, Kirsten I. Bos, Johannes Krause
bioRxiv 106740; doi: https://doi.org/10.1101/106740
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Salmonella enterica genomes recovered from victims of a major 16th century epidemic in Mexico
Åshild J. Vågene, Michael G. Campana, Nelly M. Robles García, Christina Warinner, Maria A. Spyrou, Aida Andrades Valtueña, Daniel Huson, Noreen Tuross, Alexander Herbig, Kirsten I. Bos, Johannes Krause
bioRxiv 106740; doi: https://doi.org/10.1101/106740

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