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Reproducibility2020: Progress and Priorities

Leonard P. Freedman, View ORCID ProfileGautham Venugopalan, Rosann Wisman
doi: https://doi.org/10.1101/109017
Leonard P. Freedman
1Global Biological Standards Institute, Washington, DC 20036
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Gautham Venugopalan
2Gryphon Scientific, LLC, Takoma Park, MD 20912
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Rosann Wisman
1Global Biological Standards Institute, Washington, DC 20036
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ABSTRACT

The preclinical research process is a cycle of idea generation, experimentation, and reporting of results. The biomedical research community relies on the reproducibility of published discoveries to create new lines of research and to translate research findings into therapeutic applications. Since 2012, when scientists from Amgen reported that they were able to reproduce only 6 of 53 “landmark” preclinical studies, the biomedical research community began discussing the scale of the reproducibility problem and developing initiatives to address critical challenges. GBSI released the “Case for Standards” in 2013, one of the first comprehensive reports to address the rising concern of irreproducible biomedical research. Further attention was drawn to issues that limit scientific self-correction including reporting and publication bias, underpowered studies, lack of open access to methods and data, and lack of clearly defined standards and guidelines in areas such as reagent validation. To evaluate the progress made towards reproducibility since 2013, GBSI identified and examined initiatives designed to advance quality and reproducibility. Through this process, we identified key roles for funders, journals, researchers and other stakeholders and recommended actions for future progress. This paper describes our findings and conclusions.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted February 16, 2017.
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Reproducibility2020: Progress and Priorities
Leonard P. Freedman, Gautham Venugopalan, Rosann Wisman
bioRxiv 109017; doi: https://doi.org/10.1101/109017
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Reproducibility2020: Progress and Priorities
Leonard P. Freedman, Gautham Venugopalan, Rosann Wisman
bioRxiv 109017; doi: https://doi.org/10.1101/109017

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