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Can the location of a trophectoderm biopsy contribute to human blastocyst development ?

Tomoe Takano M.Sc., Miyako Funabiki M.D., Sagiri Taguchi M.D., Ph.D., Fumie Saji Ph.D., Namiko Amano B.Sc., Kate Young Louise B.Sc., Yoshitaka Nakamura M.D.
doi: https://doi.org/10.1101/109298
Tomoe Takano M.Sc.
1)Oak Clinic, Osaka and Tokyo, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Miyako Funabiki M.D.
1)Oak Clinic, Osaka and Tokyo, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Sagiri Taguchi M.D., Ph.D.
1)Oak Clinic, Osaka and Tokyo, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Fumie Saji Ph.D.
1)Oak Clinic, Osaka and Tokyo, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Namiko Amano B.Sc.
1)Oak Clinic, Osaka and Tokyo, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Kate Young Louise B.Sc.
1)Oak Clinic, Osaka and Tokyo, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Yoshitaka Nakamura M.D.
1)Oak Clinic, Osaka and Tokyo, Japan 2-7-9 Tamade-Nishi, Nishinari-ku, Osaka, 557-0045
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Abstract

The influence of the location of a trophectoderm biopsy in human blastocysts on the development of those blastocysts has not yet been investigated. In our prospective study (n=92), our multivariate logistic regression analysis indicated that blastocoel development was influenced by the location of the trophectoderm biopsy (p=0.049) and by the type of human blastocyst used (fresh or thawed) (p=0.037), regardless of the patient’s age (p=0.507) and the number of days for the human blastocyst in the pretrophectoderm biopsy (p=0.239). Therefore, when a trophectoderm biopsy is close to the inner cell mass (ICM) in human blastocysts, it improves the progress of blastocoel development.

Clinical evidence suggests that the progress of blastocoel development is a predictor of clinical outcomes after single blastocyst transfer. Therefore, when the trophectoderm biopsy is done from near the ICM, improvement of clinical outcomes after single blastocyst transfer may be expected.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted February 20, 2017.
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Can the location of a trophectoderm biopsy contribute to human blastocyst development ?
Tomoe Takano M.Sc., Miyako Funabiki M.D., Sagiri Taguchi M.D., Ph.D., Fumie Saji Ph.D., Namiko Amano B.Sc., Kate Young Louise B.Sc., Yoshitaka Nakamura M.D.
bioRxiv 109298; doi: https://doi.org/10.1101/109298
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Can the location of a trophectoderm biopsy contribute to human blastocyst development ?
Tomoe Takano M.Sc., Miyako Funabiki M.D., Sagiri Taguchi M.D., Ph.D., Fumie Saji Ph.D., Namiko Amano B.Sc., Kate Young Louise B.Sc., Yoshitaka Nakamura M.D.
bioRxiv 109298; doi: https://doi.org/10.1101/109298

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