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MAGIC: A diffusion-based imputation method reveals gene-gene interactions in single-cell RNA-sequencing data

David van Dijk, Juozas Nainys, Roshan Sharma, Pooja Kaithail, Ambrose J. Carr, Kevin R. Moon, Linas Mazutis, Guy Wolf, Smita Krishnaswamy, Dana Pe'er
doi: https://doi.org/10.1101/111591
David van Dijk
1Program for Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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Juozas Nainys
2Sector of Microtechnologies, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania
4Department of Biological Sciences, Columbia University, New York, NY, USA
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Roshan Sharma
1Program for Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
3Department of Applied Physics and Applied Math, Columbia University, New York, NY, USA
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Pooja Kaithail
1Program for Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
4Department of Biological Sciences, Columbia University, New York, NY, USA
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Ambrose J. Carr
1Program for Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
4Department of Biological Sciences, Columbia University, New York, NY, USA
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Kevin R. Moon
5Applied Mathematics Program, Yale University, New Haven, CT, USA
6Department of Genetics, Department of Computer Science, Yale University, New Haven, CT, USA
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Linas Mazutis
1Program for Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
2Sector of Microtechnologies, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania
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Guy Wolf
5Applied Mathematics Program, Yale University, New Haven, CT, USA
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Smita Krishnaswamy
6Department of Genetics, Department of Computer Science, Yale University, New Haven, CT, USA
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Dana Pe'er
1Program for Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
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  • For correspondence: peerd@mskcc.org smita.krishnaswamy@yale.edu
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Posted February 25, 2017.
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MAGIC: A diffusion-based imputation method reveals gene-gene interactions in single-cell RNA-sequencing data
David van Dijk, Juozas Nainys, Roshan Sharma, Pooja Kaithail, Ambrose J. Carr, Kevin R. Moon, Linas Mazutis, Guy Wolf, Smita Krishnaswamy, Dana Pe'er
bioRxiv 111591; doi: https://doi.org/10.1101/111591
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MAGIC: A diffusion-based imputation method reveals gene-gene interactions in single-cell RNA-sequencing data
David van Dijk, Juozas Nainys, Roshan Sharma, Pooja Kaithail, Ambrose J. Carr, Kevin R. Moon, Linas Mazutis, Guy Wolf, Smita Krishnaswamy, Dana Pe'er
bioRxiv 111591; doi: https://doi.org/10.1101/111591

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